[Clinical effect on the treatment of the low-middle frequency sudden hearing loss with postaurical injection of methylprednisolone].

Abstract

OBJECTIVE:

To evaluate the clinical efficacy on the treatment of the low-middle frequency sudden hearing loss with postaurical injection of methylprednisolone.

METHOD:

The 80 cases of the low-middle frequency sudden hearing loss were randomly divided into postaurical injection and oral hormone groups. The postaurical injection group (42 cases) received the postaurical injection of methylprednisolone, 40 mg/2 d, combined with the treatment of Ginkgo dipyidamolum and Alprostadil for 14 d; The oral hormone group (38 cases) received the oral prednisone, 1 mg/kg/d, administrated once on the morning for 3 d, if effective, prolonging for another 2 d, as mentioned above for Ginkgo dipyidamolum and Alprostadil.

RESULT:

The total effective rate was 88.10% in postaurical injection group and 86. 4o%in oral hormone group. There was no significant difference between the twbogroups( P> 0. 5).

CONCLUSION:

Postaurical injection of methylprednisolone for the low-middle frequency sudden hearing loss is effective, safe and simple, which may be an alternative for systemic administration of gulcocorticoid.

• Authors: Sien Wu, Qingming Li, Suhong Huang
• Journal: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi) Vol. 29 Issue 10 Pg. 928-30 (May 2015) ISSN: 2096-7993 [Print] China
• PMID: 26596011 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Biological Products
• Glucocorticoids
• Alprostadil
• Prednisone
• Methylprednisolone

Topics

• Alprostadil (therapeutic use)
• Biological Products (therapeutic use)
• Glucocorticoids (administration & dosage, therapeutic use)
• Hearing Loss, Sensorineural
• Hearing Loss, Sudden (drug therapy)
• Humans
• Injections
• Methylprednisolone (administration & dosage, therapeutic use)
• Prednisone (administration & dosage, therapeutic use)
• Treatment Outcome