Crosstalk between transforming growth factor-β signaling pathway and long non-coding RNAs in cancer.

Abstract

The transforming growth factor-β (TGF-β) signaling pathway plays an important role in tumorigenesis by exerting either a tumor-suppressing or tumor-promoting effect. Long non-coding RNAs (lncRNAs), a newly discovered class of non-coding RNAs, have been widely studied in recent years and identified as crucial regulators of various biological processes, including cell cycle progression, chromatin remodeling, gene transcription, and posttranscriptional processing. Recent evidence, addressing the crosstalk between the TGF-β signaling pathway and lncRNAs in cancer, found that several members of the TGF-β pathway are targeted by lncRNAs, and the production of hundreds of lncRNAs is induced by TGF-β treatment. This review will summarize the latest progress on the investigation of TGF-β pathway and lncRNA network in regulating cancer development. Further study on the network would provide a better understanding of carcinogenesis and have potentials for the prevention and treatment of malignant diseases.

• Authors: Jianbo Wang, Na Shao, Xiaowen Ding, Bingxu Tan, Qingxu Song, Nana Wang, Yibin Jia, Hongbo Ling, Yufeng Cheng
• Journal: Cancer letters (Cancer Lett) Vol. 370 Issue 2 Pg. 296-301 (Jan 28 2016) ISSN: 1872-7980 [Electronic] Ireland
• PMID: 26577807 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• RNA, Long Noncoding
• Transforming Growth Factor beta
• Tumor Suppressor Proteins

Topics

• Humans
• Neoplasms (etiology)
• RNA, Long Noncoding (physiology)
• Signal Transduction (physiology)
• Transforming Growth Factor beta (physiology)
• Tumor Suppressor Proteins (physiology)