Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis.

Abstract	The folding of newly synthesized proteins and the maintenance of pre-existing proteins are essential in sustaining a living cell. A network of molecular chaperones tightly guides the folding, intracellular localization, and proteolytic turnover of proteins. Many of the key regulators of cell growth and differentiation have been identified as clients of molecular chaperones, which implies that chaperones are potential mediators of oncogenesis. In this review, we briefly provide an overview of the role of chaperones, including HSP70 and HSP90, in cancer. We further summarize and highlight the emerging the role of chaperonin TRiC (T-complex protein-1 ring complex, also known as CCT) in the development and progression of cancer mediated through its critical interactions with oncogenic clients that modulate growth deregulation, apoptosis, and genome instability in cancer cells. Elucidation of how TRiC modulates the folding and function of oncogenic clients will provide strategies for developing novel cancer therapies.
Authors	Soung-Hun Roh, Moses Kasembeli, Deenadayalan Bakthavatsalam, Wah Chiu, David J Tweardy
Journal	International journal of molecular sciences (Int J Mol Sci) Vol. 16 Issue 11 Pg. 26706-20 (Nov 06 2015) ISSN: 1422-0067 [Electronic] Switzerland
PMID	26561808 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
Chemical References	HSP70 Heat-Shock Proteins HSP90 Heat-Shock Proteins Neoplasm Proteins Chaperonin Containing TCP-1
Topics	Apoptosis Carcinogenesis (genetics, metabolism, pathology) Chaperonin Containing TCP-1 (genetics, metabolism) Disease Progression Gene Expression Regulation, Neoplastic Genomic Instability HSP70 Heat-Shock Proteins (genetics, metabolism) HSP90 Heat-Shock Proteins (genetics, metabolism) Humans Neoplasm Proteins (chemistry, genetics, metabolism) Neoplasms (genetics, metabolism, pathology) Protein Conformation Protein Folding Signal Transduction

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