Abstract | BACKGROUND: METHODS: Nine patients with unresectable node-negative, nonmetastatic head and neck ACC received definitive proton RT and concurrent cisplatin. Outcomes and toxicities were recorded. A systematic review of the literature was performed. RESULTS: Median follow-up was 27 months (range, 9.2-48.3 months). Four patients achieved complete response at the primary site, and an additional 4 patients achieved stabilization of local disease. Only 1 patient developed local disease progression. Four patients had 5 acute grade 3 (G3) toxicities, and 1 patient developed a chronic G4 optic nerve disorder. CONCLUSION: Our preliminary results suggest proton RT and concurrent chemotherapy is a definitive treatment option for select patients with head and neck ACC. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1472-E1480, 2016.
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Authors | Onita Bhattasali, Emma Holliday, Merrill S Kies, Ehab Y Hanna, Adam S Garden, David I Rosenthal, William H Morrison, G Brandon Gunn, C David Fuller, X Ronald Zhu, Steven J Frank |
Journal | Head & neck
(Head Neck)
Vol. 38 Suppl 1
Pg. E1472-80
(04 2016)
ISSN: 1097-0347 [Electronic] United States |
PMID | 26561041
(Publication Type: Journal Article, Review, Systematic Review)
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Copyright | © 2015 Wiley Periodicals, Inc. |
Chemical References |
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Topics |
- Adult
- Aged
- Carcinoma, Adenoid Cystic
(therapy)
- Chemoradiotherapy
- Cisplatin
(therapeutic use)
- Female
- Head and Neck Neoplasms
(therapy)
- Humans
- Male
- Middle Aged
- Proton Therapy
- Radiotherapy Dosage
- Treatment Outcome
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