Contribution of Interleukin-4 Genotypes to Lung Cancer Risk in Taiwan.

Abstract

AIM:

Lung cancer is the leading cause of cancer-related death worldwide. Interleukin-4 (IL-4) is a typical pleiotropic T helper 2 cytokine involved in immunology during carcinogenesis. The present study aimed at evaluating the contribution of IL-4 promoter T-1099G (rs2243248), C-589T (rs2243250), C-33T (rs2070874) genetic polymorphisms to the risk of lung cancer in Taiwan.

MATERIALS AND METHODS:

The contributions of the promoter IL-4 polymorphic genotypes to lung cancer risk were investigated in 358 lung cancer patients and 716 age- and gender-matched healthy controls. In addition, the interaction between IL-4 and individual smoking status was also evaluated.

RESULTS:

The percentages of CC, CT and TT for IL-4 C-589T genotypes were differentially represented as 69.0%, 26.5% and 4.5% in the lung-cancer patient group and 61.3%, 30.4% and 8.3% in the non-cancer control group, respectively (p=0.0156). The TT genotype carriers were of lower risk for lung cancer (odds ratio (OR)=0.48, 95% confidence interval (CI)=0.27-0.86, p=0.0106) than the CC genotype carriers. We also analyzed the allelic frequency distributions and the results showed that the T allele of IL-4 C-589T conducted a protective effect on lung cancer susceptibility (p=0.0022). On the contrary, there was no difference in the distribution of genotypic or allelic frequencies among patients and controls for the IL-4 promoter T-1099G and C-33T.

CONCLUSION:

The TT genotype of IL-4 C-589T compared to the CC wild-type genotype may have a protective effect on lung cancer risk in Taiwan and may serve as an early detection and prediction marker.

• Authors: Wen-Shin Chang, Shou-Cheng Wang, Chin-Liang Chuang, Hong-Xue Ji, Chieh-Lun Hsiao, Chin-Mu Hsu, Chia-Wen Tsai, Shih-Ping Liu, Pei-Chen Hsu, Yen-Li Lo, Da-Tian Bau
• Journal: Anticancer research (Anticancer Res) Vol. 35 Issue 11 Pg. 6297-301 (Nov 2015) ISSN: 1791-7530 [Electronic] Greece
• PMID: 26504066 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Chemical References

• IL10 protein, human
• Interleukin-10

Topics

• Aged
• Case-Control Studies
• Female
• Follow-Up Studies
• Genetic Predisposition to Disease
• Genotype
• Humans
• Interleukin-10 (genetics)
• Lung Neoplasms (genetics, pathology)
• Male
• Middle Aged
• Neoplasm Staging
• Polymorphism, Restriction Fragment Length
• Polymorphism, Single Nucleotide (genetics)
• Prognosis
• Promoter Regions, Genetic (genetics)
• Risk Factors
• Taiwan