Ultrasensitive self-powered cytosensors based on exogenous redox-free enzyme biofuel cells as point-of-care tools for early cancer diagnosis.

Abstract

An exogenous redox-free, membrane-less enzyme biofuel cell-based ultrasensitive self-powered cytosensing platform was fabricated. With the ultrahigh sensitivity and the merits of not requiring external power sources or exogenous reagents, the device has great potential as a point-of-care tool for early diagnosis of cancer in vivo.

• Authors: Panpan Gai, Rongbin Song, Cheng Zhu, Yusheng Ji, Wengjing Wang, Jian-Rong Zhang, Jun-Jie Zhu
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 51 Issue 94 Pg. 16763-6 (Dec 07 2015) ISSN: 1364-548X [Electronic] England
• PMID: 26443966 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Oxidoreductases Acting on CH-CH Group Donors
• bilirubin oxidase

Topics

• Bioelectric Energy Sources
• Biosensing Techniques
• Diagnostic Techniques and Procedures (instrumentation, standards)
• Electrochemical Techniques (instrumentation)
• Humans
• Limit of Detection
• Neoplasms (diagnosis)
• Oxidation-Reduction
• Oxidoreductases Acting on CH-CH Group Donors (metabolism)
• Point-of-Care Systems