Treatment of intrabony defects with guided tissue regeneration in aggressive periodontitis: clinical outcomes at 6 and 12 months.

Abstract

OBJECTIVE:

The aim of this study was to compare clinical outcomes between guided tissue regeneration (GTR) and access flap (AF) surgery in patients with aggressive periodontitis (AgP).

METHODS:

Eighteen AgP patients with similar bilateral intrabony defects were treated in this split-mouth, single-blinded, randomised, controlled clinical trial. All patients presented with ≥3 mm intrabony defects and ≥5 mm periodontal pocket depths (PPD). In each patient, one defect was treated with a polyglycolide membrane according to the GTR principle, whereas the contralateral side was treated with AF. For both sides, a simplified papilla preservation flap was used. At baseline, 6 and 12 months post-surgery, the clinical attachment levels (CAL) and PPD were evaluated.

RESULTS:

At 6 and 12 months, at the GTR sites, the mean [95 % CI] CAL gain was 1.7 mm [1.1, 2.3] and 1.6 mm [0.9, 2.1], respectively, while the mean [95 % CI] PPD reduction was 2.3 mm [1.9, 2.8] and 2.4 mm [1.9, 2.8], respectively. Similar CAL (1.6 mm [1.0, 2.2] and 2.1 mm [1.4, 2.7]) and PPD (2.0 mm [1.5, 2.4] and 2.5 mm [2.0, 3.0]) outcomes were observed at the control sites at 6 and 12 months, respectively. Notably, at the GTR-treated sites, 13 subjects presented with various degrees of membrane exposure.

CONCLUSIONS:

Both therapies were effective in the treatment of intrabony defects in AgP patients, and no statistically significant differences between them could be demonstrated, possibly as a result of the differing degrees of membrane exposure at the GTR sites.

CLINICAL RELEVANCE:

Both periodontal regeneration and conventional periodontal surgery are effective treatments for AgP patients.

• Authors: Thanasak Rakmanee, Gareth S Griffiths, Gita Auplish, Ulpee Darbar, Aviva Petrie, Irwin Olsen, Nikolaos Donos
• Journal: Clinical oral investigations (Clin Oral Investig) Vol. 20 Issue 6 Pg. 1217-25 (Jul 2016) ISSN: 1436-3771 [Electronic] Germany
• PMID: 26411859 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Membranes, Artificial

Topics

• Adolescent
• Adult
• Aggressive Periodontitis (surgery)
• Alveolar Bone Loss (surgery)
• Female
• Guided Tissue Regeneration, Periodontal (methods)
• Humans
• Male
• Membranes, Artificial
• Single-Blind Method
• Surgical Flaps
• Treatment Outcome