CD62-mediated activation of platelets in cerebral white matter lesions in patients with cognitive decline.

Abstract

BACKGROUND:

Vascular dementia is related to intracranial arteriosclerosis associated with deep white matter lesions (DWMLs). DWMLs have been linked to thrombogenesis due to sustained platelet activation; therefore, an accurate hematological marker is needed. This study was done to evaluate the usefulness of a new method to examine the function of activated platelets in order to assess DWMLs associated with cognitive decline.

METHODS:

A total of 143 individuals (70.4 ± 6.1 years old) who underwent hospital-based health screening using head MRI were evaluated. DWLs were evaluated on T2-weighted and FLAIR images by semi-quantitatively grading them from Grade 0 (none) to Grade 3 (severe) using the Fazekas classification. Cognitive function was evaluated using the MMSE and the word fluency test. Platelet activation was assessed using fluorescence-labeled anti-human platelet monoclonal antibodies and semi-quantitatively determining PAC-1- and CD62P-positive rates by flow cytometry.

RESULTS:

Significant increases in hypertension and CD62P levels were observed with increasing DWML grade (2.6% in Group 0, 3.1% in Group 1, 4.1% in Group 2, and 5.0% in Group 3). CD62P levels were defined as elevated when they were above the mean+2SD of the Grade 0 group, and the odds ratio of the Grade 2+3 group was 3.03. A significant negative correlation was observed between CD62P levels and word fluency tests or the MMSE score.

CONCLUSION:

Elevations in CD62P levels, which reflect platelet function activation, were associated with white matter lesions accompanied by a decline in cognitive function. CD62P levels may be useful as a sensitive clinical marker for the early detection of DWMLs with cognitive decline.

• Authors: Nagato Kuriyama, Toshiki Mizuno, Hiromi Yasuike, Hiroyuki Matsuno, Eri Kawashita, Aiko Tamura, Etsuko Ozaki, Daisuke Matsui, Isao Watanabe, Teruhide Koyama, Fumitaro Miyatani, Masaki Kondo, Takahiko Tokuda, Youichi Ohshima, Manabu Muranishi, Kentaro Akazawa, Akihiro Takada, Kazuo Takeda, Sanae Matsumoto, Shigeto Mizuno, Kei Yamada, Masanori Nakagawa, Yoshiyuki Watanabe
• Journal: Archives of gerontology and geriatrics (Arch Gerontol Geriatr) 2016 Jan-Feb Vol. 62 Pg. 118-24 ISSN: 1872-6976 [Electronic] Netherlands
• PMID: 26388436 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• P-Selectin
• SELP protein, human

Topics

• Aged
• Blood Platelets (pathology)
• Cognition
• Cognition Disorders (pathology)
• Dementia, Vascular
• Female
• Humans
• Hypertension (pathology)
• Intracranial Arteriosclerosis
• Magnetic Resonance Imaging
• Male
• Middle Aged
• P-Selectin (metabolism)
• Platelet Activation (physiology)
• Risk Factors
• White Matter (pathology)