Abstract |
Hepatoma is a malignant tumor that responds poorly to conventional therapies. Boron neutron capture therapy (BNCT) may provide a better way for hepatoma therapy. In this research, (10)B-enriched boric acid (BA, 99% (10)B) was used as the boron drug. A multifocal hepatic VX2 tumor-bearing rabbit model was used to study the mechanisms of BA-mediated BNCT. Autoradiography demonstrated that BA was selectively targeted to tumors and tumor vessels. Histopathological examination revealed the radiation damage to tumor-bearing liver was concentrated in the tumor regions during BNCT treatment. The selective killing of tumor cells and the destruction of the blood vessels in tumor masses may be responsible for the success of BA-mediated BNCT for liver tumors.
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Authors | C H Yang, Y T Lin, Y H Hung, J W Liao, J J Peir, H M Liu, Y L Lin, Y M Liu, Y W Chen, K S Chuang, F I Chou |
Journal | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
(Appl Radiat Isot)
Vol. 106
Pg. 176-80
(Dec 2015)
ISSN: 1872-9800 [Electronic] England |
PMID | 26372198
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 Elsevier Ltd. All rights reserved. |
Chemical References |
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Topics |
- Animals
- Autoradiography
- Boric Acids
(chemistry)
- Boron Neutron Capture Therapy
- Liver Neoplasms, Experimental
(blood supply, pathology, radiotherapy)
- Rabbits
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