Boron Neutron Capture Therapy

A technique for the treatment of neoplasms, especially gliomas and melanomas in which boron-10, an isotope, is introduced into the target cells followed by irradiation with thermal neutrons.

Also Known As:

Networked: 643 relevant articles (43 outcomes, 110 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Ono, Koji: 62 articles (12/2015 - 11/2003)
2.	Sakurai, Yoshinori: 44 articles (12/2015 - 11/2003)
3.	Suzuki, Minoru: 41 articles (12/2015 - 03/2004)
4.	Kawabata, Shinji: 33 articles (03/2015 - 11/2003)
5.	Kuroiwa, Toshihiko: 26 articles (03/2015 - 11/2003)
6.	Miyatake, Shin-Ichi: 26 articles (01/2015 - 11/2003)
7.	Maruhashi, Akira: 26 articles (06/2014 - 05/2004)
8.	Kirihata, Mitsunori: 22 articles (12/2015 - 11/2003)
9.	Barth, Rolf F: 22 articles (07/2015 - 05/2002)
10.	Schwint, Amanda E: 22 articles (03/2015 - 03/2003)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2011 - "These tumors have responded favorably to boron neutron capture therapy and the treatment has been relatively well tolerated, although most cancers have recurred locally with few cases of durable complete remission." 12/01/2015 - "The selective delivery of (10)B into the tumor tissue remains to be further improved for successful and reliable Boron Neutron Capture Therapy applications. " 10/01/2012 - "The data demonstrated that FUS significantly enhances the tumor-to-normal brain drug ratio in the sonicated tumor and subsequently the efficacy of boron neutron capture therapy." 03/30/1994 - "Boron neutron capture therapy (BNCT) offers considerable promise in the search for the ideal cancer therapy, a therapy which selectively and maximally damages malignant cells while sparing normal tissue. " 04/21/2014 - "In this study the synthesis and characterization of a new dual, imaging and therapeutic, agent is proposed with the aim of improving the efficacy of Boron Neutron Capture Therapy (BNCT) in cancer treatment. "
2.	Glioblastoma (Glioblastoma Multiforme) 11/01/2003 - "We very effectively treated two patients with recurrent glioblastoma with modified boron neutron capture therapy (BNCT). " 06/01/2014 - "Boron neutron capture therapy (BNCT) has been reported to be effective in the patients with glioblastoma multiforme (GBM). " 07/01/2009 - "To propose adequate indices predicting efficacy of boron neutron capture therapy (BNCT) for glioblastoma, a comparative treatment planning study between BNCT, 3-dimensional conformal radiotherapy (3D-CRT), and intensity-modulated radiotherapy (IMRT) was performed, and dose-volume histograms (DVHs) on planning target volume (PTV) and normal brain were calculated. " 10/01/2002 - "Improved treatment planning for boron neutron capture therapy for glioblastoma multiforme using fluorine-18 labeled boronophenylalanine and positron emission tomography." 06/01/2014 - "The purpose of this study was to clarify the correlation between the radiation dose and histopathological findings in patients with glioblastoma multiforme (GBM) treated with boron neutron capture therapy (BNCT). "
3.	Mouth Neoplasms (Oral Cancer) 04/01/2015 - "We previously reported the therapeutic efficacy of Sequential Boron Neutron Capture Therapy (Seq-BNCT), i.e., BPA (boronophenylalanine) - BNCT followed by GB-10 (decahydrodecaborate) - BNCT 1 or 2 days later, in the hamster cheek pouch oral cancer model. " 03/01/2011 - "We previously demonstrated the therapeutic efficacy of different boron neutron capture therapy (BNCT) protocols in an experimental model of oral cancer. " 02/01/2015 - "The hamster cheek pouch model of oral cancer was also proposed and validated by our group for boron neutron capture therapy studies for the treatment of oral cancer. " 04/01/2011 - "In the present study the therapeutic effect and potential toxicity of the novel "Sequential" boron neutron capture therapy (Seq-BNCT) for the treatment of oral cancer was evaluated in the hamster cheek pouch model at the RA-3 Nuclear Reactor. " 12/15/2001 - "Herein we propose and validate the hamster cheek pouch model of oral cancer for boron neutron capture therapy (BNCT) studies. "
4.	Brain Neoplasms (Brain Tumor) 03/01/2003 - "Rat brain tumor models to assess the efficacy of boron neutron capture therapy: a critical evaluation." 12/01/1996 - "An improved neutron collimator for brain tumor irradiations in clinical boron neutron capture therapy." 05/01/2015 - "Recent studies have shown that D-T neutron generator can be used as a proper neutron source for Boron Neutron Capture Therapy (BNCT) of deep-seated brain tumors. " 12/01/2005 - "Neutron activation of patients following boron neutron capture therapy of brain tumors at the high flux reactor (HFR) Petten (EORTC Trials 11961 and 11011)." 09/01/2004 - "These findings suggest that compound 10 is a promising candidate for selective delivery of boron-10 to malignant cells, and additional in vivo studies are planned to evaluate it for boron neutron capture therapy of brain tumors."
5.	Melanoma (Melanoma, Malignant) 03/30/1994 - "The present study was carried out to determine the efficacy of Boron Neutron Capture Therapy (BNCT) for intracerebral melanoma using nude rats, the human melanoma cell line MRA 27, and boronophenylalanine as the capture agent. " 10/01/2015 - "Experimental Studies of Boronophenylalanine ((10)BPA) Biodistribution for the Individual Application of Boron Neutron Capture Therapy (BNCT) for Malignant Melanoma Treatment." 01/01/2004 - "Boron neutron capture therapy of skin melanomas at the RA-6 reactor: a procedural approach to beam set up and performance evaluation for upcoming clinical trials." 02/01/1999 - "Pharmacokinetics of 10B-p-boronophenylalanine in tumours, skin and blood of melanoma patients: a study of boron neutron capture therapy for malignant melanoma." 10/01/2015 - "Patients with the same histopathologic diagnosis of cutaneous melanoma treated with identical protocols of boron neutron capture therapy (BNCT) have shown different clinical outcomes. "

Related Drugs and Biologics

1.	Boron
2.	4-boronophenylalanine
3.	Liposomes (Liposome)
4.	Phenylalanine (L-Phenylalanine)
5.	Fructose
6.	boric acid (boron oxide hydroxide)
7.	4-boronophenylalanine-fructose
8.	N-acetylcochinol-O-phosphate
9.	bevacizumab
10.	Niacinamide (Nicotinamide)

Related Therapies and Procedures

1.	Radiotherapy
2.	Intensity-Modulated Radiotherapy (Radiotherapy, Intensity Modulated)
3.	Conformal Radiotherapy
4.	Photochemotherapy (Photodynamic Therapy)
5.	Nuclear Reactors