A Food-Derived Flavonoid Luteolin Protects against Angiotensin II-Induced Cardiac Remodeling.

Abstract

Oxidative stress has been implicated in cardiac remodeling (cardiac fibrosis and hypertrophy), which impairs cardiac function and metabolism; therefore, it is anticipated antioxidative compounds will have protective properties against cardiac remodeling. Luteolin (3',4',5,7-tetrahydroxyflavone), a widely distributed flavonoid found in many herbal extracts including celery, green pepper, perilla leaves and seeds, and chamomile, is a known to be a potent antioxidant and was previously demonstrated to exert an antifibrotic effect in the lungs and the liver. In this study, we clearly demonstrate that oral pretreatment with the higher-luteolin diet (0.035% (wt/wt)) protected against cardiac fibrosis and hypertrophy as well as a hyperoxidative state in Ang II-infused rats. In cardiac tissue, increased gene expression levels of TGFβ1, CTGF, Nox2, Nox4, ANP, and BNP induced by Ang II were restored by oral pretreatment of this high-luteolin diet. In cultured rat cardiac fibroblasts, H2O2-induced TGFβ1 expression and the phosphorylation of JNK were suppressed by luteolin pretreatment. In conclusion, food-derived luteolin has protective actions against Ang II-induced cardiac remodeling, which could be mediated through attenuation of oxidative stress.

• Authors: Atsuko Nakayama, Hiroyuki Morita, Tomoko Nakao, Toshihiro Yamaguchi, Tomokazu Sumida, Yuichi Ikeda, Hidetoshi Kumagai, Yoshihiro Motozawa, Tsukasa Takahashi, Atsushi Imaizumi, Tadashi Hashimoto, Ryozo Nagai, Issei Komuro
• Journal: PloS one (PLoS One) Vol. 10 Issue 9 Pg. e0137106 ( 2015) ISSN: 1932-6203 [Electronic] United States
• PMID: 26327560 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• CCN2 protein, rat
• Flavonoids
• Transforming Growth Factor beta1
• Angiotensin II
• Connective Tissue Growth Factor
• Atrial Natriuretic Factor
• Hydrogen Peroxide
• Luteolin

Topics

• Angiotensin II (pharmacology)
• Animals
• Antioxidants (pharmacology)
• Atrial Natriuretic Factor (metabolism)
• Connective Tissue Growth Factor (metabolism)
• Diet
• Fibroblasts (drug effects, metabolism)
• Fibrosis (drug therapy, metabolism)
• Flavonoids (pharmacology)
• Food
• Heart (drug effects)
• Hydrogen Peroxide (pharmacology)
• Hypertrophy (drug therapy, metabolism)
• Luteolin (pharmacology)
• Male
• Myocardium (metabolism)
• Oxidative Stress (drug effects)
• Phosphorylation (drug effects)
• Rats
• Rats, Sprague-Dawley
• Signal Transduction (drug effects)
• Transforming Growth Factor beta1 (metabolism)
• Ventricular Remodeling (drug effects)