Abstract | INTRODUCTION: AREAS COVERED: The HER family of receptors and their pathways, pertuzumab pharmacodynamics and preclinical activity, results from the main clinical trials, new drug combinations being developed, and predictors of response are discussed. EXPERT OPINION:
Pertuzumab represents an important anti-HER2 agent that differs from, but is synergistic with, trastuzumab. It is already a standard of care in the first-line treatment of HER2-positive metastatic BC, and studies are ongoing to define its role in the adjuvant setting. It is now imperative to identify which tumors need dual HER2 targeting and to study the activity of pertuzumab in combination with other HER-targeted agents, including anti-HER1, -HER3 or -HER4, which could also prove useful in HER2-normal cancers. Potential competitors are anti-HER3 antibodies and bi- or tri-specific antibodies. Development in combination with phosphoinositide 3-kinase inhibitors or with anti PD-L1 is warranted.
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Authors | Andrea Rocca, Daniele Andreis, Anna Fedeli, Roberta Maltoni, Samanta Sarti, Lorenzo Cecconetto, Elisabetta Pietri, Alessio Schirone, Sara Bravaccini, Patrizia Serra, Alberto Farolfi, Dino Amadori |
Journal | Expert opinion on drug metabolism & toxicology
(Expert Opin Drug Metab Toxicol)
Vol. 11
Issue 10
Pg. 1647-63
( 2015)
ISSN: 1744-7607 [Electronic] England |
PMID | 26307328
(Publication Type: Journal Article, Review)
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Chemical References |
- Antibodies, Monoclonal, Humanized
- ERBB2 protein, human
- Receptor, ErbB-2
- pertuzumab
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Topics |
- Animals
- Antibodies, Monoclonal, Humanized
(administration & dosage, pharmacokinetics, pharmacology)
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, pharmacokinetics, pharmacology)
- Breast Neoplasms
(drug therapy, pathology)
- Disease-Free Survival
- Drug Synergism
- Female
- Humans
- Receptor, ErbB-2
(metabolism)
- Survival Rate
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