[Kinase inhibitors and their resistance].

Abstract	Kinase cascades are involved in all stages of tumorigenesis through modulation of transformation and differentiation, cell-cycle progression, and motility. Advances in molecular targeted drug development allow the design and synthesis of inhibitors targeting cancer-associated signal transduction pathways. Potent selective inhibitors with low toxicity can benefit patients especially with several malignancies harboring an oncogenic driver addictive signal. This article evaluates information on solid tumor-related kinase signals and inhibitors, including receptor tyrosine kinase or serine/threonine kinase signals that lead to successful application in clinical settings. In addition, the resistant mechanisms to the inhibitors is summarized.
Authors	Yosuke Togashi, Kazuto Nishio
Journal	Nihon rinsho. Japanese journal of clinical medicine (Nihon Rinsho) Vol. 73 Issue 8 Pg. 1323-9 (Aug 2015) ISSN: 0047-1852 [Print] Japan
PMID	26281685 (Publication Type: Journal Article, Review)
Chemical References	Antibodies, Monoclonal, Humanized Benzamides Biomarkers, Tumor Indoles Phenylurea Compounds Piperazines Protein Kinase Inhibitors Pyrazoles Pyridines Pyrimidines Quinazolines Sulfonamides Vemurafenib Niacinamide Crizotinib Imatinib Mesylate Sorafenib Protein Kinases EGFR protein, human ErbB Receptors Trastuzumab Gefitinib
Topics	Antibodies, Monoclonal, Humanized Benzamides Biomarkers, Tumor (analysis) Crizotinib Drug Discovery Drug Resistance, Neoplasm ErbB Receptors Gefitinib Humans Imatinib Mesylate Indoles Molecular Targeted Therapy Neoplasms (diagnosis, drug therapy, enzymology, genetics) Niacinamide (analogs & derivatives) Phenylurea Compounds Piperazines Protein Kinase Inhibitors (pharmacology, therapeutic use) Protein Kinases (physiology) Pyrazoles Pyridines Pyrimidines Quinazolines Signal Transduction (drug effects, genetics) Sorafenib Sulfonamides Trastuzumab Vemurafenib

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!