Association of plasma osteoprotegerin levels with the severity of lower extremity arterial disease in patients with type 2 diabetes.

Abstract

BACKGROUND:

Osteoprotegerin (OPG) is a member of the tumor necrosis factor receptor superfamily and suggested as a marker of atherosclerosis. However, little is known about the association between plasma OPG levels and lower extremity arterial disease. We investigated whether plasma OPG levels were associated with the presence and severity of lower extremity arterial disease in patients with type 2 diabetes.

METHODS:

This was a study of 712 patients with type 2 diabetes aged 40 years or older. Plasma OPG was measured using ELISA. The lower extremity arterial disease was diagnosed by high-frequency color Doppler ultrasonic.

RESULTS:

Of 712 patients, 505 (70.9 %) had lower extremity arterial stenosis. OPG levels were significantly increased in patients with lower extremity arterial stenosis [1.89 (1.48-2.41) vs. 2.39 (1.82-3.33) ng/mL, p < 0.001]. Plasma OPG levels increased gradually with increasing severity of lower extremity arterial stenosis (p < 0.001 for trend), after adjustment for traditional cardiovascular risk factors such as age, gender, smoking, total cholesterol, high-density lipoprotein (HDL) cholesterol, C-reactive protein (CRP), body mass index (BMI), systolic blood pressure(SBP). The risk of lower extremity arterial disease was increased (OR = 1.17, 95 % CI 1.09 -1.28, p < 0.001) with each standard deviation (SD) higher level of OPG in patients with type 2 diabetes after adjustment for traditional CVD risk factors.

CONCLUSIONS:

Plasma OPG levels were significantly associated with the presence and severity of lower extremity arterial disease. Our results suggest that OPG is an important plasma biomarker of lower extremity arterial disease in type 2 diabetes.

• Authors: Yixin Niu, Weiwei Zhang, Zhen Yang, Xiaoyong Li, Jie Wen, Suijun Wang, Hongmei Zhang, Xuanchun Wang, Houguang Zhou, Wenjun Fang, Li Qin, Qing Su
• Journal: BMC cardiovascular disorders (BMC Cardiovasc Disord) Vol. 15 Pg. 86 (Aug 11 2015) ISSN: 1471-2261 [Electronic] England
• PMID: 26260869 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• ADIPOQ protein, human
• Adiponectin
• Osteoprotegerin
• TNFRSF11B protein, human
• C-Reactive Protein

Topics

• Adiponectin (blood)
• Adult
• Aged
• C-Reactive Protein (metabolism)
• Cohort Studies
• Constriction, Pathologic (blood, diagnostic imaging)
• Diabetes Mellitus, Type 2 (blood, complications)
• Female
• Humans
• Lower Extremity (blood supply, diagnostic imaging)
• Male
• Middle Aged
• Osteoprotegerin (blood)
• Peripheral Arterial Disease (blood, complications, diagnostic imaging)
• Prospective Studies
• Severity of Illness Index
• Ultrasonography, Doppler, Color