The role of high cholesterol-high fructose diet on coronary arteriosclerosis.
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| Abstract |
The effect of fructose in conjunction with high cholesterol diet in the development of atherosclerotic lesions in coronary arteries is not well established. Microswine were fed high cholesterol (HC) or a high cholesterol-high fructose (HCHF) diet containing 18-20% calories from fructose. All swine had high levels of serum cholesterol and non-HDL, thickened intima and accumulation of collagen in the coronaries. Swine fed with HC diet had less stenosis in coronary arteries, lower serum levels of non-HDL, triglycerides, cholesterol, and blood glucose than HCHF group. Coronary lesions in the HC swine were not as progressed as in HCHF and showed low LDL-expressed lipid-laden foam cells. The M1/M2 macrophage phenotype in the HCHF swine differed with the progression of atherosclerosis, with higher density of M1-phenotype in HCHF swine. There was high expression of CCR7 (M1-phenotype) in more advanced lesions in the fibrous cap-like areas, whereas M2-macrophages were abundant in the foam-cell cores. These findings suggest that the addition of a fructose to high cholesterol diet accelerates atherosclerotic lesions in coronary arteries with an increase in M1-macrophages and the propensity to develop features of metabolic syndrome.
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| Authors | Vicki J Swier, Lin Tang, Mohamed M Radwan, William J Hunter 3rd, Devendra K Agrawal |
| Journal | Histology and histopathology (Histol Histopathol) Vol. 31 Issue 2 Pg. 167-76 (Feb 2016) ISSN: 1699-5848 [Electronic] Spain |
| PMID | 26260796 (Publication Type: Journal Article, Research Support, N.I.H., Extramural) |
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