Cisplatin Plus Ifosfamide with/without Etoposide as Salvage Treatment in Heavily-pre-treated Patients with Metastatic Breast Cancer.

Abstract

BACKGROUND:

The efficacy of platinum- and ifosfamide-based chemotherapy regimens as salvage treatment in metastatic breast cancer (MBC) has not yet been sufficiently evaluated.

PATIENTS AND METHODS:

Patients with MBC treated with cisplatin plus ifosfamide with (PEI) and without (PI) etoposide in our clinic between 04/2005 and 04/2014 were retrospectively analyzed.

RESULTS:

A total of 20 patients (median four prior chemotherapies) treated with PEI/PI were identified, out of whom 18 were evaluable for objective response. Treatment with PEI/PI resulted in one complete remission, nine partial remissions and two cases of stable disease. The median (range) progression-free survival was 4 (0-18) months and median overall survival from therapy initiation was 8.5 (0-50) months. PEI/PI therapy caused grade 3/4 toxicities (mainly hematological) in 80% of patients.

CONCLUSION:

PEI/PI is an adequate salvage treatment for patients with MBC but cannot be generally recommended due to toxicity. However, comparison with platinum monotherapy trials suggests that PEI/PI might be a more effective treatment for patients with triple-negative breast cancer.

• Authors: Piet Habbel, Annika Kurreck, Carsten-Oliver Schulz, Anne Constanze Regierer, David Kaul, Christian Wilfried Scholz, Christian Neumann, Kurt Possinger, Jan Eucker
• Journal: Anticancer research (Anticancer Res) Vol. 35 Issue 9 Pg. 5091-5 (Sep 2015) ISSN: 1791-7530 [Electronic] Greece
• PMID: 26254412 (Publication Type: Journal Article)
• Copyright: Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Chemical References

• Antineoplastic Agents
• Etoposide
• Cisplatin
• Ifosfamide

Topics

• Antineoplastic Agents (adverse effects, therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Breast Neoplasms (drug therapy, secondary)
• Cisplatin (adverse effects, therapeutic use)
• Disease-Free Survival
• Etoposide (adverse effects, therapeutic use)
• Female
• Humans
• Ifosfamide (adverse effects, therapeutic use)
• Salvage Therapy
• Treatment Outcome