Abstract | OBJECTIVE: METHODS: Two cases of biopsy-proven oxalate nephropathy were identified among systemic sclerosis patients in the course of direct clinical care. Subsequently, a retrospective search of the Johns Hopkins Pathology databases identified a third patient with systemic sclerosis who developed oxalate nephropathy. RESULTS: Among the three patients with qualifying biopsies, all three had systemic sclerosis with lower gastrointestinal involvement. All three presented with diarrhea, malabsorption, and AKI. In two of the three patients, diarrhea was present for at least 2 years before the development of AKI; in the third, incidental oxalate nephropathy was noted 3 years before she developed AKI and extensive oxalate nephropathy in the setting of a prolonged mycobacterium avium-intracellulare enteritis. In the first case, oxalate crystals were present by urinalysis months before diagnosis by biopsy; in the second, hyperoxaluria was diagnosed by urine collection immediately after; and in the third, oxalate crystals had been noted incidentally on post-transplant renal biopsy 3 years before the development of fulminant oxalate nephropathy. All three patients died within a year after diagnosis. CONCLUSIONS:
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Authors | Colin B Ligon, Laura K Hummers, Zsuzsanna H McMahan |
Journal | Seminars in arthritis and rheumatism
(Semin Arthritis Rheum)
Vol. 45
Issue 3
Pg. 315-20
(Dec 2015)
ISSN: 1532-866X [Electronic] United States |
PMID | 26239907
(Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Extramural, Review)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Acute Kidney Injury
(complications, urine)
- Aged
- Female
- Humans
- Hyperoxaluria
(complications, urine)
- Middle Aged
- Oxalic Acid
(urine)
- Scleroderma, Systemic
(complications, urine)
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