Intravenous immunoglobulin replacement induces an in vivo reduction of inflammatory monocytes and retains the monocyte ability to respond to bacterial stimulation in patients with common variable immunodeficiencies.
|
| Abstract |
Intravenous IgG administration induces significant modifications in the innate and adaptive compartment of the immune system including the monocyte/macrophage system. We analyzed the in vivo effect of IgG administered at replacement dosages on the frequency of monocytes subsets, on the modulation of CD11b and sialic acid-binding immunoglobulin-like lectin receptor (Siglec 9) expression and on monocytes production of reactive oxygen species. We showed that patients with Common Variable Immune Deficiency have an increased frequency pro-inflammatory intermediate CD14(++)CD16(+) monocytes and an increased expression of CD11b and Siglec 9 on monocytes. IgG administered at replacement dosages exerted an in vivo anti-inflammatory effect as shown by a reduction of circulating monocytes, of intermediate pro-inflammatory monocytes, of CD11b and Siglec 9 expression and of ex vivo monocytes oxidative burst. Nevertheless, intravenous IgG administration did not affect the monocyte functional ability to respond to a bacterial stimulation in terms of CD11b and Siglec 9 expression and reactive oxygen species production.
|
|---|---|
| Authors | Filomena Monica Cavaliere, Alessandro Prezzo, Valentina Conti, Caterina Bilotta, Federica Pulvirenti, Metello Iacobini, Isabella Quinti |
| Journal | International immunopharmacology (Int Immunopharmacol) Vol. 28 Issue 1 Pg. 596-603 (Sep 2015) ISSN: 1878-1705 [Electronic] Netherlands |
| PMID | 26232049 (Publication Type: Controlled Clinical Trial, Journal Article) |
| Copyright | Copyright © 2015. Published by Elsevier B.V. |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!