Abstract | INTRODUCTION: EVIDENCE ACQUISITION: In the present article, we reviewed, with a systematic literature search through May 2015, currently available clinical studies investigating the association of aortic diseases with OSA. EVIDENCE SYNTHESIS: It is suggested that OSA is highly prevalent in patients with aortic diseases and associated with aortic expansion. Through the nocturnal perturbations of intermittent hypoxia, intrathoracic pressure swings, and increased sympathetic neural activation, OSA patients appear to be at increased risk for vascular changes related to oxidative stress, inflammation, and endothelial dysfunction, which may present as risks for aortic diseases. Despite currently available findings, it remains unclear whether common etiology leads to both OSA and aortic diseases or whether OSA itself causes aortic diseases. CONCLUSIONS: The following types of studies with long-term follow-up would be required: 1) a prospective cohort study comparing the incidence of aortic diseases in OSA patients with that in non-OSA subjects and 2) a randomized controlled trial determining whether CPAP therapy for OSA reduces the incidence of aortic diseases.
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Authors | Hisato Takagi, Takuya Umemoto |
Journal | International angiology : a journal of the International Union of Angiology
(Int Angiol)
Vol. 35
Issue 5
Pg. 433-9
(Oct 2016)
ISSN: 1827-1839 [Electronic] Italy |
PMID | 26221978
(Publication Type: Journal Article, Review)
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Topics |
- Aged
- Aortic Diseases
(diagnosis, epidemiology, mortality)
- Female
- Humans
- Male
- Middle Aged
- Prevalence
- Prognosis
- Risk Assessment
- Risk Factors
- Severity of Illness Index
- Sleep Apnea, Obstructive
(diagnosis, epidemiology, mortality)
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