The role of CDCP1 (CUB domain-containing protein 1) and ADAM12 (a disintegrin and metalloproteinase 12) in ovarian cancer.

Abstract

Ovarian cancer (OC) is the second most common gynecological cancer and the deadliest in industrialized countries, with poor outcomes that indicate an urgent need to provide a greater insight into the molecular mechanisms underlying OC. Insights into the complex tumor microenviroment show that besides tumor islets, OC biomarkers can derive from newly formed blood vessels that have endothelial cells with a different molecular signature in comparison with their normal counterparts. In this view, recent research has been able to highlight promising candidates such as CDCP1 and ADAM12. Our present review summarises their implications in cancer progression with a focus on OC.

• Authors: Catalin Vlad, Paul Kubelac, Andrea Onisim, Alexandru Irimie, Patriciu Achimas-Cadariu
• Journal: Journal of B.U.ON. : official journal of the Balkan Union of Oncology (J BUON) 2015 May-Jun Vol. 20 Issue 3 Pg. 673-9 ISSN: 1107-0625 [Print] Cyprus
• PMID: 26214617 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antigens, CD
• Antigens, Neoplasm
• Biomarkers, Tumor
• CDCP1 protein, human
• Cell Adhesion Molecules
• Membrane Proteins
• Neoplasm Proteins
• ADAM Proteins
• ADAM12 Protein
• ADAM12 protein, human

Topics

• ADAM Proteins (metabolism)
• ADAM12 Protein
• Animals
• Antigens, CD (metabolism)
• Antigens, Neoplasm
• Biomarkers, Tumor (metabolism)
• Cell Adhesion Molecules (metabolism)
• Disease Progression
• Endothelial Cells (enzymology)
• Female
• Humans
• Membrane Proteins (metabolism)
• Neoplasm Invasiveness
• Neoplasm Proteins (metabolism)
• Ovarian Neoplasms (blood supply, enzymology, pathology)
• Signal Transduction
• Tumor Microenvironment