Effect of vitamin K2 on progression of atherosclerosis and vascular calcification in nondialyzed patients with chronic kidney disease stages 3-5.

Abstract

INTRODUCTION:

Observational studies have shown that high dietary intake of vitamin K2 is associated with reduced risk of coronary vascular disease and vascular calcification.

OBJECTIVES:

We assessed the effect of vitamin K2 substitution on the progression of atherosclerosis and calcification in nondialyzed patients with CKD stages 3-5.

PATIENTS AND METHODS:

The study included 42 nondialyzed patients with CKD. The following measurements were taken at baseline and after 270 ±12 days of supplementation with vitamin K2 at a dose of 90 μg (menaquinone, MK-7) together with 10 μg of cholecalciferol (K+D group) or 10 μg of cholecalciferol (group D): common carotid intima-media thickness (CCA-IMT), coronary artery calcification score (CACS), basic biochemical parameters, lipids, and calcification modulators: matrix Gla protein (MGP), desphosphorylated-uncarboxylated MGP (dp-ucMGP), osteoprotegerin (OPG), fetuin A, osteocalcin (OC), and fibroblast growth factor 23.

RESULTS:

The increase of CCA-IMT was significantly lower in the K+D group compared with the D group: from 0.95 ±0.2 mm to 1.01 ±0.3, P = 0.003 vs from 1.02 ±0.2 mm to 1.16 ±0.3, P = 0.003 (ΔCCA-IMT, 0.06 ±0.08 vs 0.136 ±0.05 mm, P = 0.005, respectively). The increase in CACS was slightly lower in the K+D group than in the D group (ΔCACS, 58.1 ±106.5 AU vs 74.4 ±127.1 AU, P = 0.7). In the K+D group, a significant decrease in the level of dp-ucMGP and total OC was observed.

CONCLUSIONS:

A 270-day course of vitamin K2 administration in patients with CKD stages 3-5 may reduce the progression of atherosclerosis, but does not significantly affect the progression of calcification. Vitamin K2 significantly changes the levels of calcification promoters and inhibitors: dp-ucMGP, OC, and OPG.

• Authors: Ilona Kurnatowska, Piotr Grzelak, Anna Masajtis-Zagajewska, Magdalena Kaczmarska, Ludomir Stefańczyk, Cees Vermeer, Katarzyna Maresz, Michał Nowicki
• Journal: Polskie Archiwum Medycyny Wewnetrznej (Pol Arch Med Wewn) Vol. 125 Issue 9 Pg. 631-40 ( 2015) Poland
• PMID: 26176325 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Vitamin K 2

Topics

• Adult
• Aged
• Atherosclerosis (drug therapy, pathology)
• Carotid Intima-Media Thickness
• Dietary Supplements
• Disease Progression
• Double-Blind Method
• Female
• Humans
• Male
• Middle Aged
• Prospective Studies
• Random Allocation
• Renal Insufficiency, Chronic (drug therapy, pathology)
• Vascular Calcification (drug therapy, pathology)
• Vitamin K 2 (pharmacology)
• White People