Abstract | AIMS: Worrying data indicate that excessive caffeine intake applies to patients suffering from mental disorders, including depression. It is thus possible to demonstrate the usefulness of caffeine and its derivatives in the treatment of depression. The main goal of the present studywas to evaluate the influence of caffeine (5mg/kg) on the activity of moclobemide (1.5 mg/kg), venlafaxine (1 mg/kg), bupropion (10 mg/kg), and milnacipran (1.25 mg/kg). Moreover, we assessed the influence of caffeine on their serum and brain levels using highperformance liquid chromatography. MAIN METHODS: The experiment was carried out on naïve adult male Albino Swiss mice. Caffeine and tested drugs were administered intraperitoneally. The influence of caffeine on the activity of selected antidepressant drugs was evaluated in forced swim test (FST). Locomotor activity was estimated to verify and exclude false positive/negative results. To assess the influence of caffeine on the levels of studied antidepressant drugs, their concentrations were determined in murine serum and brains using high-performance liquid chromatography. KEY FINDINGS:
Caffeine potentiated activity of all antidepressants examined in FST and the observed effects were not due to the increase in locomotor activity in the animals. Only in the case of co-administration of caffeine and milnacipran an increased milnacipran concentration in serum was observed without affecting its concentration in the brain. SIGNIFICANCE:
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Authors | Ewa Poleszak, Aleksandra Szopa, Elżbieta Wyska, Sylwia Wośko, Anna Serefko, Aleksandra Wlaź, Mateusz Pieróg, Andrzej Wróbel, Piotr Wlaź |
Journal | Life sciences
(Life Sci)
Vol. 136
Pg. 13-8
(Sep 01 2015)
ISSN: 1879-0631 [Electronic] Netherlands |
PMID | 26135623
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antidepressive Agents, Second-Generation
- Cyclohexanols
- Cyclopropanes
- Bupropion
- Caffeine
- Venlafaxine Hydrochloride
- Milnacipran
- Moclobemide
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Topics |
- Animals
- Antidepressive Agents, Second-Generation
(pharmacology)
- Bupropion
(pharmacokinetics, pharmacology)
- Caffeine
(pharmacokinetics, pharmacology)
- Cyclohexanols
(pharmacokinetics, pharmacology)
- Cyclopropanes
(pharmacokinetics, pharmacology)
- Drug Evaluation, Preclinical
- Drug Interactions
- Male
- Mice
- Milnacipran
- Moclobemide
(pharmacokinetics, pharmacology)
- Motor Activity
(drug effects)
- Swimming
- Venlafaxine Hydrochloride
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