[Impact of glutamine, eicosapntemacnioc acid, branched-chain amino acid supplements on nutritional status and treatment compliance of esophageal cancer patients on concurrent chemoradiotherapy and gastric cancer patients on chemotherapy].

Abstract

OBJECTIVE:

To explore the effects of glutamine, eicosapntemacnioc acid (EPA) and branched-chain amino acids supplements in esophageal cancer patients on concurrent chemoradiotherapy and gastric cancer patients on chemotherapy.

METHODS:

From April 2013 to April 2014, a total of 104 esophageal and gastric carcinoma patients on chemotherapy or concurrent chemoradiotherapy were recruited and randomly divided into experimental and control groups. Both groups received dietary counseling and routine nutritional supports while only experimental group received supplements of glutamine (20 g/d), EPA (3.3 g/d) and branched-chain amino acids (8 g/d). And body compositions, blood indicators, incidence of complications and completion rates of therapy were compared between two groups.

RESULTS:

After treatment, free fat mass and muscle weight increased significantly in experiment group while decreased in control group (P < 0.05). And albumin, red blood cell count, white blood cell count and blood platelet count remained stable in experiment group while declined significantly in control group. During treatment, compared to control group, the incidences of infection-associated complication were lower (6% vs 19%, P < 0.05) and the completion rates of therapy were significantly higher in experiment group (96% vs 83%, P < 0.05).

CONCLUSION:

Supplements of glutamine, EPA and branched-chain amino acids can help maintain nutrition status, decrease the complications and improve compliance for esophageal cancer patients on concurrent chemo-radiotherapy and gastric cancer patients on postoperative adjuvant chemotherapy.

• Authors: Minghua Cong, Chenxin Song, Baohua Zou, Yingbing Deng, Shuluan Li, Xuehui Liu, Weiwei Liu, Jinying Liu, Lei Yu, Binghe Xu
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 95 Issue 10 Pg. 766-9 (Mar 17 2015) ISSN: 0376-2491 [Print] China
• PMID: 26080850 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Amino Acids, Branched-Chain
• Glutamine

Topics

• Amino Acids, Branched-Chain
• Chemoradiotherapy
• Chemotherapy, Adjuvant
• Dietary Supplements
• Esophageal Neoplasms
• Glutamine
• Humans
• Nutritional Status
• Nutritional Support
• Patient Compliance
• Stomach Neoplasms