Abstract | OBJECTIVE: METHODS: We conducted a monocentric retrospective study including 42 EGPA patients who had consecutively undergone CMRI at diagnosis or during follow-up, independently of signs of cardiac involvement. RESULTS: Forty-two patients (male 59.5%, mean age at diagnosis 46.5 years) were included. ANCA was positive in 26.2%, and median EGPA duration before the 1st CMRI screening was 5 months. Seventeen (40.5%) were diagnosed with cardiomyopathy, independently of CMRI findings. CMRI showed myocardial late gadolinium enhancement (LGE) in 82.4% patients with cardiomyopathy vs. 44% without cardiomyopathy (P=0.024). Using LGE as the sole criterion, CMRI sensitivity and specificity for diagnosing cardiomyopathy were 82.4% and 56%, respectively. Among the 15 patients with cardiomyopathy who underwent additional CMRI during follow-up, CMRI-detected cardiac lesions had improved in 7 patients, while those of 8 patients worsened or stabilized despite treatment. These latter patients presented with significantly more cardiac events during follow-up (P=0.026). No differences were found between non-cardiomyopathic patients with or without CMRI anomalies concerning EGPA cardiac manifestations and outcomes. CONCLUSION: The diagnostic significance of myocardial LGE in EGPA patients remains uncertain and should not be the only criterion for cardiomyopathy diagnosis. For patients with no other signs of cardiomyopathy, CMRI-detected anomalies do not seem to adversely affect prognosis or outcome. For patients with cardiomyopathy, CMRI reassessment seems promising in detecting patients with a less favorable cardiac outcome.
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Authors | Bertrand Dunogué, Benjamin Terrier, Pascal Cohen, Julien Marmursztejn, Paul Legmann, Luc Mouthon, Denis Duboc, Olivier Vignaux, Loïc Guillevin, French Vasculitis Study Group |
Journal | Autoimmunity reviews
(Autoimmun Rev)
Vol. 14
Issue 9
Pg. 774-80
(Sep 2015)
ISSN: 1873-0183 [Electronic] Netherlands |
PMID | 25960167
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2015 Elsevier B.V. All rights reserved. |
Topics |
- Eosinophils
- Granulomatosis with Polyangiitis
(pathology)
- Humans
- Magnetic Resonance Imaging
(methods)
- Myocardium
(pathology)
- Prognosis
- Retrospective Studies
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