Continuous topical irrigation for severely infected wound healing.
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| Abstract | BACKGROUND: Management of severely infected wounds is a formidable challenge. The pilot prospective cohort study is to investigate the influence of continuous topical irrigation (CTI) on the outcomes of severely infected wounds. METHODS: This pilot study was performed on 17 patients with a single severely infected wound treated with CTI, compared with a control group of 15 patients treated with standard of care from January 2011-January 2013. Bates-Jensen wound assessment tool severity scores and the clinical outcomes were recorded. Profiles of cytokines and/or proteinase in wound fluid were quantified weekly. RESULTS: Comparing with the control, the CTI-treated patients required fewer days for wound infection clearance (8 ± 2 versus 19 ± 5 d, P < 0.001), had wounds closed earlier (17 ± 4 versus 36 ± 7 d, P < 0.001), and had fewer inhospital stay days (23 ± 5 versus 42 ± 8 d, P < 0.001). Bates-Jensen wound assessment tool severity scorings, proinflammatory cytokines (tumor necrosis factor-α, interleukin 1β, and interleukin 6), and matrix metalloproteinase-8 were significantly decreased in response to CTI. CONCLUSIONS: This pilot study demonstrates that CTI improves severely infected wound healing through partly inhibiting proinflammatory cytokines and improving tissue regeneration.
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| Authors | Qingsong Tao, Jianan Ren, Zhenling Ji, Baochai Wang, Yu Zheng, Jieshou Li |
| Journal | The Journal of surgical research (J Surg Res) Vol. 198 Issue 2 Pg. 535-40 (Oct 2015) ISSN: 1095-8673 [Electronic] United States |
| PMID | 25958167 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't) |
| Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
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