Adversomics: a new paradigm for vaccine safety and design.

Abstract

Despite the enormous population benefits of routine vaccination, vaccine adverse events (AEs) and reactions, whether real or perceived, have posed one of the greatest barriers to vaccine acceptance--and thus to infectious disease prevention--worldwide. A truly integrated clinical, translational, and basic science approach is required to understand the mechanisms behind vaccine AEs, predict them, and then apply this knowledge to new vaccine design approaches that decrease, or avoid, these events. The term 'adversomics' was first introduced in 2009 and refers to the study of vaccine adverse reactions using immunogenomics and systems biology approaches. In this review, we present the current state of adversomics research, review known associations and mechanisms of vaccine AEs/reactions, and outline a plan for the further development of this emerging research field.

• Authors: Jennifer A Whitaker, Inna G Ovsyannikova, Gregory A Poland
• Journal: Expert review of vaccines (Expert Rev Vaccines) Vol. 14 Issue 7 Pg. 935-47 (Jul 2015) ISSN: 1744-8395 [Electronic] England
• PMID: 25937189 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Vaccines

Topics

• Biomedical Research (trends)
• Drug-Related Side Effects and Adverse Reactions (epidemiology, prevention & control)
• Humans
• Immunogenetics (methods)
• Patient Acceptance of Health Care
• Systems Biology (methods)
• Vaccines (administration & dosage, adverse effects)