Analysis of 65 pregnancies in 34 women with five different forms of inherited platelet function disorders.

Abstract

This study evaluated 65 pregnancies in 34 women with five different inherited platelet function disorders. Gestation was similar to that of the general population. Severe bleeds requiring blood transfusions were observed in 50% of deliveries in Glanzmann thrombasthenia (GT), but not in the patients with delta storage pool disease, Hermansky-Pudlak syndrome, P2Y12 defect or defect of thromboxane A2 receptor. Of note, severe haemorrhage also occurred in women with GT who had received prophylactic platelet transfusions, suggesting that better preventive treatments are required. Diagnosis and degree of spontaneous bleeding tendency before pregnancy were reliable parameters to predict the delivery-related bleeding risk.

• Authors: Elisa Civaschi, Catherine Klersy, Federica Melazzini, Nuria Pujol-Moix, Cristina Santoro, Marco Cattaneo, Cécile Lavenu-Bombled, Loredana Bury, Pietro Minuz, Paquita Nurden, Ana R Cid, Adam Cuker, Véronique Latger-Cannard, Remi Favier, Ilaria Nichele, Patrizia Noris, European Haematology Association - Scientific Working Group on Thrombocytopenias and Platelet Function Disorders
• Journal: British journal of haematology (Br J Haematol) Vol. 170 Issue 4 Pg. 559-63 (Aug 2015) ISSN: 1365-2141 [Electronic] England
• PMID: 25899604 (Publication Type: Clinical Trial, Journal Article, Multicenter Study)
• Copyright: © 2015 John Wiley & Sons Ltd.

Topics

• Adolescent
• Adult
• Blood Platelet Disorders (therapy)
• Female
• Hemorrhage (prevention & control)
• Humans
• Middle Aged
• Platelet Transfusion
• Pregnancy
• Pregnancy Complications, Hematologic (therapy)