Abstract | BACKGROUND: METHODS: RESULTS: Time to reperfusion was similar between the 2 groups. The QRS score before PCI was higher in group L than in group H (2.42±2.00 vs 1.85±2.01, p=0.015). The proportion of patients with I/R injury immediately after reperfusion, defined as reperfusion ventricular arrhythmias (25% vs 11%, p=0.006) and ST-segment re-elevation (44% vs 22%, p<0.001), was also higher in group L than in group H, followed by a greater increment in the QRS score during PCI (3.51±2.51 vs 2.54±1.91, p=0.006) and higher peak levels of creatinine phosphokinase (3552±241U/L vs 2660±242U/L, p<0.01). On multivariate analysis, serum level of EPA+DHA was an independent predictor of reperfusion injury (odds ratio 0.985, p=0.032). CONCLUSION: Serum level of n-3 PUFAs before PCI may be a predictor of I/R injury and the resultant extent of myocardial damage. These findings suggest a protective effect of serum n-3 PUFAs on ischemic myocardium.
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Authors | Kentaro Arakawa, Hideo Himeno, Jin Kirigaya, Fumie Otomo, Kensuke Matsushita, Hidefumi Nakahashi, Satoru Shimizu, Manabu Nitta, Hideto Yano, Mitsuaki Endo, Kazuo Kimura, Satoshi Umemura |
Journal | Journal of cardiology
(J Cardiol)
Vol. 66
Issue 2
Pg. 101-7
(Aug 2015)
ISSN: 1876-4738 [Electronic] Netherlands |
PMID | 25847089
(Publication Type: Evaluation Study, Journal Article)
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Copyright | Copyright © 2015 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- Biomarkers
- Docosahexaenoic Acids
- Eicosapentaenoic Acid
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Topics |
- Aged
- Biomarkers
(blood)
- Disease Progression
- Docosahexaenoic Acids
(blood)
- Eicosapentaenoic Acid
(blood)
- Female
- Humans
- Male
- Middle Aged
- Myocardial Infarction
(diagnostic imaging, surgery)
- Myocardial Reperfusion Injury
(diagnostic imaging, etiology)
- Odds Ratio
- Percutaneous Coronary Intervention
(adverse effects)
- Predictive Value of Tests
- Radiography
- Time Factors
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