Chemokine-mediated immune responses in the female genital tract mucosa.

Abstract

The genital tract mucosa is the site where sexually transmitted infections gain entry to the host. The immune response at this site is thus critical to provide innate protection against pathogens that are seen for the very first time as well as provide long-term pathogen-specific immunity, which would be required for an effective vaccine against sexually transmitted infection. A finely regulated immune response is therefore required to provide an effective barrier against pathogens without compromising the capacity of the genital tract to allow for successful conception and fetal development. We review recent developments in our understanding of the immune response in the female genital tract to infectious pathogens, using herpes simplex virus-2, human immunodeficiency virus-1 and Chlamydia trachomatis as examples, with a particular focus on the role of chemokines in orchestrating immune cell migration necessary to achieve effective innate and adaptive immune responses in the female genital tract.

• Authors: Maud Deruaz, Andrew D Luster
• Journal: Immunology and cell biology (Immunol Cell Biol) Vol. 93 Issue 4 Pg. 347-54 (Apr 2015) ISSN: 1440-1711 [Electronic] United States
• PMID: 25776842 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)

Chemical References

• Chemokines
• Vaccines

Topics

• Adaptive Immunity
• Animals
• Cell Movement
• Chemokines (immunology)
• Chlamydia Infections (immunology)
• Chlamydia trachomatis (immunology)
• Female
• Genitalia, Female (immunology, microbiology, virology)
• HIV Infections (immunology)
• HIV-1 (immunology)
• Herpes Genitalis (immunology)
• Herpesvirus 2, Human (immunology)
• Humans
• Immunity, Mucosal
• Vaccines