Abstract |
The traditional herb Plumula Nelumbinis is widely used in the world because it has many biological activities, such as anti- inflammation, antioxidant, antihypertension, and butyrylcholinesterase inhibition. However, the action of Plumula Nelumbinis on airway smooth muscle (ASM) relaxation has not been investigated. A chloroform extract of Plumula Nelumbinis (CEPN) was prepared, which completely inhibited precontraction induced by high K(+) in a concentration-dependent manner in mouse tracheal rings, but it had no effect on resting tension. CEPN also blocked voltage-dependent L-type Ca(2+) channel- ( VDCC-) mediated currents. In addition, ACh-induced precontraction was also completely blocked by CEPN and partially inhibited by nifedipine or pyrazole 3. Besides, CEPN partially reduced ACh-activated nonselective cation channel (NSCC) currents. Taken together, our data demonstrate that CEPN blocked VDCC and NSCC to inhibit Ca(2+) influx, resulting in relaxation of precontracted ASM. This finding indicates that CEPN would be a candidate of new potent bronchodilators.
|
Authors | Li Tan, Weiwei Chen, Ming-Yu Wei, Jinhua Shen, Meng-Fei Yu, Guangzhong Yang, Donglin Guo, Gangjian Qin, Guangju Ji, Qing-Hua Liu |
Journal | Evidence-based complementary and alternative medicine : eCAM
(Evid Based Complement Alternat Med)
Vol. 2015
Pg. 523640
( 2015)
ISSN: 1741-427X [Print] United States |
PMID | 25763092
(Publication Type: Journal Article)
|