[A case report of neuroendocrine carcinoma of the stomach with liver metastases curatively resected after neoadjuvant chemotherapy].

Abstract

The patient was a 73-year-old male with advanced gastric cancer in the lesser curvature of the antrum.Abdominal computed tomography revealed multiple liver metastases(S5, S8).He was diagnosed with clinical Stage IV gastric cancer (cT3N0M1H1).He received 3 courses of combined neoadjuvant chemotherapy with capecitabine, cisplatin, and trastuzumab because immunostaining indicated the tumor was human epidermal growth factor receptor 2(HER2)-positive.The therapeutic response, as assessed by imaging studies, was partial for the primary lesions and stable for liver metastases.Distal gastrectomy, D2 lymph node dissection, and S5 extended subsegmentectomy of the liver were performed.Histopathological findings indicated that both the primary tumor and liver metastases were neuroendocrine carcinoma.The patient declined post-operative adjuvant chemotherapy and he is alive 6 months after the surgery with no evidence of recurrence.Surgery with neoadjuvant chemotherapy appears to be a promising option for advanced gastric cancer with liver metastases.

• Authors: Kentaro Hokonohara, Akihiro Takata, Takehiro Noda, Hiroshi Imamura, Masashi Hirota, Kazuteru Oshima, Tsukasa Tanida, Hisanori Hatano, Takamichi Komori, Shunji Morita, Takashi Iwazawa, Kenzo Akagi, Shiro Adachi, Keizo Dono
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 41 Issue 12 Pg. 2287-9 (Nov 2014) ISSN: 0385-0684 [Print] Japan
• PMID: 25731498 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antibodies, Monoclonal, Humanized
• Deoxycytidine
• Capecitabine
• Trastuzumab
• Cisplatin
• Fluorouracil

Topics

• Aged
• Antibodies, Monoclonal, Humanized (administration & dosage)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Capecitabine
• Carcinoma, Neuroendocrine (drug therapy, secondary, surgery)
• Cisplatin (administration & dosage)
• Deoxycytidine (administration & dosage, analogs & derivatives)
• Fluorouracil (administration & dosage, analogs & derivatives)
• Gastrectomy
• Hepatectomy
• Humans
• Liver Neoplasms (drug therapy, secondary, surgery)
• Male
• Neoadjuvant Therapy
• Stomach Neoplasms (drug therapy, pathology, surgery)
• Trastuzumab