Host Nonresponsiveness Does not Interfere With Vaccine-Mediated Protection Against Gastric Helicobacter Infection.

Abstract

BACKGROUND:

Helicobacter pylori pathogenesis results from the inflammation induced by chronic infection. CBA mice are nonresponsive to gastric Helicobacter infection, providing a useful model for examining host regulation of Helicobacter-induced gastritis. We examined whether gastric Helicobacter nonresponsiveness impacts upon vaccine efficacy and whether immune-mediated protection could occur in the absence of inflammation.

METHODS:

Mice were vaccinated prior to challenge with Helicobacter felis or H. pylori. Gastritis and H. felis colonization was evaluated histologically. H. pylori colonization was quantified by colony-forming assay.

RESULTS:

Immunizations protected CBA mice against challenge with either H. felis or H. pylori. Protection against H. felis was marked by a loss of nonresponsiveness and development of an atrophic gastritis with mucus metaplasia. However, vaccine-induced protection against H. pylori was only associated with cell infiltration into the gastric mucosa.

CONCLUSIONS:

Nonresponsiveness to gastric Helicobacter infection did not interfere with vaccination-induced protection. Vaccine-induced protective immunity against H. pylori was linked with the induction of cellular infiltration, but importantly not atrophic gastritis.

• Authors: Stacey N Harbour, Hazel M Mitchell, Philip Sutton
• Journal: Helicobacter (Helicobacter) Vol. 20 Issue 3 Pg. 217-22 (Jun 2015) ISSN: 1523-5378 [Electronic] England
• PMID: 25683672 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 John Wiley & Sons Ltd.

Chemical References

• Antibodies, Bacterial
• Bacterial Vaccines

Topics

• Animals
• Antibodies, Bacterial (immunology)
• Bacterial Vaccines (immunology)
• Disease Models, Animal
• Female
• Gastric Mucosa (immunology)
• Gastritis, Atrophic (immunology, prevention & control)
• Helicobacter (immunology)
• Helicobacter Infections (immunology, prevention & control)
• Helicobacter felis (immunology)
• Helicobacter pylori (immunology)
• Humans
• Immunization
• Inflammation
• Metaplasia (pathology)
• Mice
• Mice, Inbred CBA
• Stomach (immunology)