Second and third-look endoscopy for the prevention of post-ESD bleeding.

Abstract

The efficacy of 2nd-look esophagogastroduodenoscopy (EGD) with endoscopic hemostatic therapy (EHT) for the prevention of postendoscopic submucosal dissection (ESD) clinical bleeding remains controversial. The aim of this study was to estimate post-ESD bleeding rate using 2nd and 3rd-look strategy, and to determine risk factors for clinical bleeding, and for EHT at 2nd and 3rd-look EGDs.Three hundred forty-four consecutive patients with early gastric cancer or adenoma underwent ESD from January 2006 through March 2012. Second and 3rd-look EGDs were performed on day 1 (D1) and day 7 (D7), respectively, with EHT as needed.Post-ESD clinical bleeding rate was 2.6% (95% confidence interval [CI] 1.2%-4.9%). For clinical bleeding, adjusted odds ratios (ORs) for age <65 years and antithrombotic drug uses were 4.40 (95% CI 1.07-19.93) and 7.34 (95% CI 1.80-32.48), respectively. For D1 EHT, adjusted ORs of tumor location in the lower part of the stomach and maximum tumor diameter ≥60 mm were 2.16 (95% CI 1.35-3.51) and 2.20 (95% CI 1.05-4.98), respectively. For D7 EHT, adjusted OR of D1 EHT was 4.65 (95% CI 1.56-20.0).Post-ESD clinical bleeding rate was relatively low using 2nd and 3rd-look strategy. Age <65 years and antithrombotic drug use are significant risk factors for clinical bleeding. Regarding EHT, tumor location in the lower part of the stomach and maximum diameter of resected specimen ≥60 mm are significant predictors for D1 EHT. D1 EHT in turn is a significant risk factor for D7 EHT. The efficacy of sequential strategy for preventing post-ESD bleeding is promising.

• Authors: Shunsuke Tano, Noriyuki Horiki, Fumio Omata, Kyosuke Tanaka, Yasuhiko Hamada, Masaki Katsurahara, Katsuhito Ninomiya, Kenichiro Nishikawa, Keiichiro Nojiri, Reiko Yamada, Hiroyuki Inoue, Esteban C Gabazza, Naoyuki Katayama, Yoshiyuki Takei
• Journal: Medicine (Medicine (Baltimore)) Vol. 94 Issue 6 Pg. e491 (Feb 2015) ISSN: 1536-5964 [Electronic] United States
• PMID: 25674738 (Publication Type: Journal Article)

Chemical References

• Fibrinolytic Agents

Topics

• Age Factors
• Aged
• Endoscopy, Digestive System
• Endoscopy, Gastrointestinal
• Female
• Fibrinolytic Agents (adverse effects)
• Hemostatic Techniques
• Humans
• Male
• Postoperative Hemorrhage (etiology, prevention & control)
• Risk Factors
• Second-Look Surgery
• Stomach Neoplasms (surgery)
• Treatment Outcome