Abstract | OBJECTIVE: METHODS: We conducted a cross-sectional study consisting of 1551 participants from the National Heart, Lung and Blood Institute Family Heart Study to assess the relation of Apo E polymorphism with the prevalence of MetS. MetS was defined according to the American Heart Association-National Heart, Lung and Blood Institute-International Diabetes Federation-World Health Organization harmonized criteria. We used generalized estimating equations to estimate adjusted odds ratios ( ORs) for prevalent MetS and the Bonferroni correction to account for multiple testing in the secondary analysis. RESULTS: Our study population had a mean age (standard deviation) of 56.5 (11.0) years, and 49.7% had MetS. There was no association between the Apo E genotypes and the MetS. The multivariable adjusted ORs (95% confidence interval) were 1.00 (reference), 1.26 (0.31-5.21), 0.89 (0.62-1.29), 1.13 (0.61-2.10), 1.13 (0.88-1.47) and 1.87 (0.91-3.85) for the Ɛ3/Ɛ3, Ɛ2/Ɛ2, Ɛ2/Ɛ3, Ɛ2/Ɛ4, Ɛ3/Ɛ4 and Ɛ4/Ɛ4 genotypes, respectively. In a secondary analysis, Ɛ2/Ɛ3 genotype was associated with 41% lower prevalence odds of low high-density lipoprotein [multivariable adjusted ORs (95% confidence interval) = 0.59 (0.36-0.95)] compared with Ɛ3/Ɛ3 genotype. CONCLUSIONS: Our findings do not support an association between Apo E polymorphism and MetS in a multicentre population-based study of predominantly White US men and women.
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Authors | Lana Y H Lai, Andrew B Petrone, James S Pankow, Donna K Arnett, Kari E North, R Curtis Ellison, Steven C Hunt, James L Rosenzweig, Luc Djoussé |
Journal | Diabetes/metabolism research and reviews
(Diabetes Metab Res Rev)
Vol. 31
Issue 6
Pg. 582-7
(Sep 2015)
ISSN: 1520-7560 [Electronic] England |
PMID | 25656378
(Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2015 John Wiley & Sons, Ltd. |
Chemical References |
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Topics |
- Aged
- Apolipoproteins E
(genetics, metabolism)
- Cross-Sectional Studies
- Family Health
- Female
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Male
- Metabolic Syndrome
(epidemiology, genetics, metabolism)
- Middle Aged
- National Heart, Lung, and Blood Institute (U.S.)
- Polymorphism, Genetic
- Prevalence
- United States
(epidemiology)
- White People
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