Trials of vaccines for pancreatic ductal adenocarcinoma: Is there any hope of an improved prognosis?

Abstract	Pancreatic tumors are chemoresistant and malignant, and there are very few therapeutic options for pancreatic cancer, as the disease is normally diagnosed at an advanced stage. Although attempts have been made to develop vaccine therapies for pancreatic cancer for a couple of decades, none of the resultant protocols or regimens have succeeded in improving the clinical outcomes of patients. We herein review vaccines tested within the past few years, including peptide, biological and multiple vaccines, and describe the three sets of criteria used to evaluate the therapeutic activity of vaccines in solid tumors.
Authors	Toru Mizuguchi, Toshihiko Torigoe, Fukino Satomi, Hiroaki Shima, Goro Kutomi, Shigenori Ota, Masayuki Ishii, Hiroshi Hayashi, Sumiyo Asakura, Yoshihiko Hirohashi, Makoto Meguro, Yasutoshi Kimura, Toshihiko Nishidate, Kenji Okita, Masaho Ishino, Atsushi Miyamoto, Masamitsu Hatakenaka, Noriyuki Sato, Koichi Hirata
Journal	Surgery today (Surg Today) Vol. 46 Issue 2 Pg. 139-48 (Feb 2016) ISSN: 1436-2813 [Electronic] Japan
PMID	25649538 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References	BIRC5 protein, human Bacterial Vaccines Cancer Vaccines Carcinoembryonic Antigen GVAX vaccine Gastrins Heat-Shock Proteins Inhibitor of Apoptosis Proteins KIF20A protein, human MUC1 protein, human Mucin-1 Peptides Survivin Vaccines, Attenuated Viral Vaccines WT1 Proteins WT1 protein, human gastrin immunogen KDR protein, human Vascular Endothelial Growth Factor Receptor-2 TERT protein, human Telomerase Kinesins
Topics	Bacterial Vaccines Cancer Vaccines (therapeutic use) Carcinoembryonic Antigen Carcinoma, Pancreatic Ductal (therapy) Clinical Trials as Topic Fowlpox virus Gastrins Genes, ras (genetics) Heat-Shock Proteins Inhibitor of Apoptosis Proteins Kinesins Listeria monocytogenes Mucin-1 Mutation Pancreatic Neoplasms (therapy) Peptides Survivin Telomerase Vaccines, Attenuated Vascular Endothelial Growth Factor Receptor-2 Viral Vaccines WT1 Proteins

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