[Pemetrexed nephrotoxicity].

Abstract

Pemetrexed belongs to a new generation of multitargeted antifolate cytotoxic agents. It is increasingly used as first-line treatment in combination with cisplatin, and as second-line treatment or maintenance monotherapy mainly in metastatic non-small cell lung cancer and in malignant mesothelioma. It is increasingly used as first-line treatment in combination with cisplatin in lung adenocarcinoma, and as second-line treatment or maintenance monotherapy in patients mainly controlled by the first-line to progression or poor tolerance. In mesothelioma, pemetrexed is indicated only in first-line with a platinum salt. The main side effect of pemetrexed is myelosuppression, which may be prevented by folinic acid supplementation. This review focuses on the progressive and cumulative emerging renal toxicity of pemetrexed, affecting five to ten percent of "long-term" pemetrexed-treated patients.

• Authors: Hassan Izzedine
• Journal: Bulletin du cancer (Bull Cancer) Vol. 102 Issue 2 Pg. 190-7 (Feb 2015) ISSN: 1769-6917 [Electronic] France
• Vernacular Title: Néphrotoxicité du pemetrexed.
• PMID: 25641712 (Publication Type: English Abstract, Journal Article, Review)
• Copyright: Copyright © 2014 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

Chemical References

• Antimetabolites, Antineoplastic
• Glutamates
• Pemetrexed
• Guanine
• Leucovorin

Topics

• Antimetabolites, Antineoplastic (adverse effects, pharmacokinetics)
• Antineoplastic Combined Chemotherapy Protocols (adverse effects)
• Bone Marrow (drug effects)
• Clinical Trials as Topic
• Glutamates (adverse effects, pharmacokinetics)
• Guanine (adverse effects, analogs & derivatives, antagonists & inhibitors, pharmacokinetics)
• Humans
• Kidney (drug effects)
• Leucovorin (administration & dosage)
• Neutropenia (chemically induced, prevention & control)
• Pemetrexed