Erythrocytic hydrogen sulfide production is increased in children with vasovagal syncope.

Abstract

OBJECTIVES:

To explore the differences in erythrocyte hydrogen sulfide (H2S) production in children with vasovagal syncope (VVS).

STUDY DESIGN:

A total of 54 children including 27 with VVS, aged 6-16 years (mean age 11.3 ± 3.3 years), and 27 healthy children, aged 3-17 years (mean age 10.4 ± 1.8 years) were included in the study. Children with VVS had symptoms of dizziness, pallor, blurred vision, nausea, and some had syncope. Erythrocyte H2S production was measured by a sulphur-sensitive electrode. Flow-mediated dilation (FMD) of brachial artery was measured for each patient by vascular ultrasound.

RESULTS:

H2S production from erythrocytes was significantly increased in the children with VVS compared with controls (P < .01). The erythrocytic H2S production in the VVS-vasoinhibitory subgroup was obviously higher than that in VVS-cardioinhibitory (P < .05) and VVS-mixed inhibitory subgroups (P < .05). FMD in the VVS-vasoinhibitory subgroup was greater than that in the VVS-cardioinhibitory (P < .05) and the VVS-mixed subgroups (P < .05). The erythrocytic H2S production had a positive linear correlation with FMD in children with VVS (P < .05).

CONCLUSIONS:

Increased erythrocyte H2S production may be involved in the pathogenesis of VVS in children.

• Authors: Jinyan Yang, Hongxia Li, Todd Ochs, Juan Zhao, Qingyou Zhang, Shuxu Du, Yonghong Chen, Ping Liu, Yuli Wang, Xueli Feng, Chunyu Zhang, Chaoshu Tang, Junbao Du, Hongfang Jin
• Journal: The Journal of pediatrics (J Pediatr) Vol. 166 Issue 4 Pg. 965-9 (Apr 2015) ISSN: 1097-6833 [Electronic] United States
• PMID: 25641243 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Hydrogen Sulfide

Topics

• Adolescent
• Biomarkers (blood)
• Child
• Child, Preschool
• Disease Progression
• Electrocardiography
• Erythrocytes (metabolism)
• Female
• Follow-Up Studies
• Heart Rate (physiology)
• Humans
• Hydrogen Sulfide (blood)
• Male
• ROC Curve
• Syncope, Vasovagal (blood, diagnosis, physiopathology)
• Tilt-Table Test