High-temperature-required protein A2 as a predictive marker for response to chemotherapy and prognosis in patients with high-grade serous ovarian cancers.

Abstract

BACKGROUND:

High-temperature-required protein A2 (HtrA2), a protein relating with apoptosis in a caspases-dependent and non-dependent manner, has been reported to be associated with chemosensitivity in several human cancers.

METHODS:

Tissue microarrays made from 142 patients with high-grade serous ovarian adenocarcinoma were evaluated to assess whether HtrA2 expression was related with several clinical parameters.

RESULTS:

Negative HtrA2 expression was observed in 36 cases (25%) of the patients, and related with significantly lower response rates of primary chemotherapy than those with positive HtrA2 expression (56% vs 83%, P<0.01). In addition, negative HtrA2 expression was identified as an independent worse prognostic factor for progression-free survival and overall survival by multivariate analyses. Furthermore, HtrA2 downregulation modulated sensitivity to platinum in serous ovarian cancer cells in vitro.

CONCLUSIONS:

HtrA2 expression was a predictor for sensitivity to chemotherapy, and could be a candidate of molecular target in the treatment of high-grade serous ovarian cancers.

• Authors: M Miyamoto, M Takano, K Iwaya, N Shinomiya, T Goto, M Kato, A Suzuki, T Aoyama, J Hirata, I Nagaoka, H Tsuda, K Furuya
• Journal: British journal of cancer (Br J Cancer) Vol. 112 Issue 4 Pg. 739-44 (Feb 17 2015) ISSN: 1532-1827 [Electronic] England
• PMID: 25628093 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Mitochondrial Proteins
• Serine Endopeptidases
• HTRA2 protein, human
• High-Temperature Requirement A Serine Peptidase 2

Topics

• Adult
• Aged
• Aged, 80 and over
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Biomarkers, Tumor (metabolism)
• Cell Line, Tumor
• Cystadenocarcinoma, Serous (diagnosis, drug therapy, metabolism, pathology)
• Disease-Free Survival
• Female
• High-Temperature Requirement A Serine Peptidase 2
• Humans
• Middle Aged
• Mitochondrial Proteins (physiology)
• Neoplasm Grading
• Ovarian Neoplasms (diagnosis, drug therapy, metabolism, pathology)
• Prognosis
• Serine Endopeptidases (physiology)
• Treatment Outcome