Kindler syndrome protein Kindlin-1 is mainly expressed in adult tissues originating from ectoderm/endoderm.

Abstract	Mutations of integrin-interacting protein Kindlin-1 cause Kindler syndrome and deregulation of Kindlin-1 is implicated in human cancers. The Kindlin-1-related diseases are confined in limited tissue types. However, Kindlin-1 tissue distribution and the dogma that governs Kindlin-1 expression in normal human body are elusive. This study examined Kindlin-1 expression in normal human adult organs, human and mouse embryonic organs by immunohistochemical analyses. We identified a general principle that the level of Kindlin-1 expression in tissues is tightly correlated with the corresponding germ layers from which these tissues originate. We compared the expression of Kindlin-1 with Kindlin-2 and found that Kindlin-1 is highly expressed in epithelial tissues derived from ectoderm and endoderm, whereas Kindlin-2 is mainly expressed in mesoderm-derived tissues. Likewise, Kindlin-1 was also found highly expressed in endoderm/ectoderm-derived tissues in human and mouse embryos. Our findings indicate that Kindlin-1 may play an importance role in the development of endoderm/ectoderm related tissues.
Authors	Jun Zhan, Mei Yang, Jing Zhang, YongQing Guo, Wei Liu, HongQuan Zhang
Journal	Science China. Life sciences (Sci China Life Sci) Vol. 58 Issue 5 Pg. 432-41 (May 2015) ISSN: 1869-1889 [Electronic] China
PMID	25591451 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Carrier Proteins FERMT1 protein, human FERMT3 protein, human Membrane Proteins Neoplasm Proteins kindlin-1 protein, mouse
Topics	Adult Animals Blister (embryology, genetics, metabolism) Carrier Proteins (genetics, metabolism) Ectoderm (embryology, metabolism) Endoderm (embryology, metabolism) Epidermolysis Bullosa (embryology, genetics, metabolism) Female Gene Expression Humans Immunohistochemistry Membrane Proteins (genetics, metabolism) Mesoderm (embryology, metabolism) Mice Mice, Inbred ICR Neoplasm Proteins (genetics, metabolism) Neoplasms (metabolism) Periodontal Diseases (embryology, genetics, metabolism) Photosensitivity Disorders (embryology, genetics, metabolism) Pregnancy Tissue Distribution

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