Abstract | INTRODUCTION: METHODS: RESULTS:
Oral administration of Harkány thermal spring water significantly attenuated general signs of colitis, MPO enzyme activity of colon samples and detrimental effect of colitis on the function of the enteric nervous system, but not histological signs of colitis. These findings could be reproduced using NaHS solution with additional significantly diminished histological damage. CONCLUSIONS: We conclude that oral treatment with Harkány thermal spring water relieves various aspects of DSS-evoked colitis in mice. This effect is most likely to be mediated by hydrogen sulfide content of the Harkány water. Our data might promote complementary utilization of sulfurous thermal spring water in the therapy of inflammatory bowel disease.
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Authors | Gábor Pozsgai, Rita Benkó, Loránd Barthó, Katalin Horváth, Erika Pintér |
Journal | Inflammopharmacology
(Inflammopharmacology)
Vol. 23
Issue 1
Pg. 57-64
(Feb 2015)
ISSN: 1568-5608 [Electronic] Switzerland |
PMID | 25556814
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drinking Water
- Sulfides
- Dextran Sulfate
- sodium bisulfide
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Topics |
- Animals
- Colitis
(chemically induced, pathology, prevention & control)
- Dextran Sulfate
(toxicity)
- Drinking Water
(administration & dosage)
- Hot Springs
- Male
- Mice
- Mice, Inbred C57BL
- Sulfides
(administration & dosage)
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