Expression of vascular endothelial growth factor in deep second-degree scald wounds in rats.

Abstract

OBJECTIVE:

To observe the expression of vascular endothelial growth factor(VEGF)in deep second-degree scald wounds,with an attempt to further explore the role of VEGF in burn wound healing.

METHODS:

Totally 36 adult Wistar rats were randomized into two groups: the scald group(30 rats)and the control group(6 rats). In the scald group,rat models of deep second-degree scald wounds were established. Full-thickness tissues of the wounds were collected respectively 1,3,7,14,and 21 days after the modeling. The expressions of the VEGF mRNA and protein were detected with real-time quantitative PCR and Western blot,respectively. In the control group,the same procedures were performed but without modeling.

RESULTS:

Compared with the control group,the expressions of VEGF mRNA and proteins were significantly higher in the scald group(P<0.05). The expression levels reached the peak on day 1,gradually decreased on day 3,reached the lowest points on day 14,but increased again on day 21.

CONCLUSIONS:

VEGF is involved in the healing of scald burns. The expression of VEGF during the wound healing is closely correlated with the wound angiogenesis.

• Authors: Qi Wu, Jia-Han Wang, Zhi-Qing Li, Jia-Liang Ren, Yong-Heng Wu
• Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae (Zhongguo Yi Xue Ke Xue Yuan Xue Bao) Vol. 36 Issue 6 Pg. 650-3 (Dec 2014) ISSN: 1000-503X [Print] China
• PMID: 25556741 (Publication Type: Journal Article)

Chemical References

• Vascular Endothelial Growth Factor A

Topics

• Animals
• Burns (metabolism)
• Neovascularization, Pathologic
• Rats
• Rats, Wistar
• Vascular Endothelial Growth Factor A (metabolism)
• Wound Healing (physiology)