Anti-cancer, pharmacokinetics and tumor localization studies of pH-, RF- and thermo-responsive nanoparticles.

Abstract

The curcumin-encapsulated chitosan-graft-poly(N-vinyl caprolactam) nanoparticles containing gold nanoparticles (Au-CRC-TRC-NPs) were developed by ionic cross-linking method. After "optimum RF exposure" at 40 W for 5 min, Au-CRC-TRC-NPs dissipated heat energy in the range of ∼42°C, the lower critical solution temperature (LCST) of chitosan-graft-poly(N-vinyl caprolactam), causing controlled curcumin release and apoptosis to cancer cells. Further, in vivo PK/PD studies on swiss albino mice revealed that Au-CRC-TRC-NPs could be sustained in circulation for a week with no harm to internal organs. The colon tumor localization studies revealed that Au-CRC-TRC-NPs were retained in tumor for a week. These results throw light on their feasibility as multi-responsive nanomedicine for RF-assisted cancer treatment modalities.

• Authors: N Sanoj Rejinold, Reju George Thomas, Muthunarayanan Muthiah, K P Chennazhi, K Manzoor, In-Kyu Park, Yong Yeon Jeong, R Jayakumar
• Journal: International journal of biological macromolecules (Int J Biol Macromol) Vol. 74 Pg. 249-62 (Mar 2015) ISSN: 1879-0003 [Electronic] Netherlands
• PMID: 25526695 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier B.V. All rights reserved.

Chemical References

• Antineoplastic Agents, Phytogenic
• Caprolactam
• Gold
• Chitosan
• Curcumin

Topics

• Animals
• Antineoplastic Agents, Phytogenic (administration & dosage, pharmacology)
• Apoptosis (drug effects)
• Caprolactam (chemistry)
• Cell Line, Tumor
• Chitosan (chemistry)
• Curcumin (administration & dosage, pharmacology)
• Disease Models, Animal
• Drug Delivery Systems
• Gold (chemistry)
• Humans
• Hydrogen-Ion Concentration
• Mice
• Nanoparticles (chemistry)
• Neoplasms (pathology, therapy)
• Particle Size
• Pulsed Radiofrequency Treatment
• Thermodynamics
• Tissue Distribution
• Tumor Burden (drug effects, radiation effects)