Abstract | OBJECTIVE: METHOD: RESULT: Thirty-nine cases were male and 43 cases were female. The epilepsy syndromes included 49 patients diagnosed as benign childhood epilepsy with centrotemporal spike (BECT) variants, 27 patients diagnosed as epilepsy with continuous spikes and waves during slow sleep (CSWS), and 6 patients diagnosed as LKS. Age of onset ranged from 1 year and 4 months to 11 years. The age of ESES newly monitored was from 2 years to 10 years and 8 months. The total effective rate of corticosteroid was 83% (68/82) for ESES, BECT variants was 82% (40/49), CSWS was 81% (22/27), LKS was 100% (6/6). There was no statistically significant difference in effective rates between the front two (χ² = 0.09, P > 0.05). The seizures were improved in the first month after methylprednisolone treatment in 3 epilepsy syndromes. The recurrence rate of BECT variants was 47% (23/49) , CSWS was 59% (16/27) , LKS was 50% (3/6) after 1 year follow up. There was no association between disease parameters, including age at seizure onset, duration of ESES and the treatment effect of ESES examined by Kruskal-Wallis method (χ² = 3.585, 0.932, P > 0.05). CONCLUSION:
Methylprednisolone was effective for improving ESES and seizures in 3 epilepsy syndromes combined with ESES. There was no significant correlation between age at seizure onset, duration of ESES and treatment effect of ESES.
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Authors | Jing Chen, Zhixian Yang, Xiaoyan Liu, Taoyun Ji, Na Fu, Ye Wu, Hui Xiong, Shuang Wang, Xingzhi Chang, Yuehua Zhang, Xinhua Bao, Yuwu Jiang, Jiong Qin |
Journal | Zhonghua er ke za zhi = Chinese journal of pediatrics
(Zhonghua Er Ke Za Zhi)
Vol. 52
Issue 9
Pg. 678-82
(Sep 2014)
ISSN: 0578-1310 [Print] China |
PMID | 25476430
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Adrenal Cortex Hormones
- Methylprednisolone
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Topics |
- Adrenal Cortex Hormones
(therapeutic use)
- Child
- Child, Preschool
- Electroencephalography
- Female
- Humans
- Infant
- Landau-Kleffner Syndrome
(drug therapy, physiopathology)
- Male
- Methylprednisolone
(therapeutic use)
- Pediatrics
- Seizures
(prevention & control)
- Sleep
(physiology)
- Status Epilepticus
(drug therapy, physiopathology)
- Treatment Outcome
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