Drug-Eluting Beads Loaded With Doxorubicin (DEBDOX) Chemoembolisation Before Liver Transplantation for Hepatocellular Carcinoma: An Imaging/Histologic Correlation Study.

Abstract

PURPOSE:

Most transplant centers use chemoembolisation as locoregional bridge therapy for hepatocellular carcinoma (HCC) before liver transplantation (LT). Chemoembolisation using beads loaded with doxorubicin (DEBDOX) is a promising technique that enables delivery of a large quantity of drugs against HCC. We sought to assess the imaging-histologic correlation after DEBDOX chemoembolisation.

MATERIALS AND METHODS:

All consecutive patients who had undergone DEBDOX chemoembolisation before receiving liver graft for HCC were included. Tumour response was evaluated according to Response Evaluation Criteria in Solid Tumours (RECIST) and modified RECIST (mRECIST) criteria. The result of final imaging made before LT was correlated with histological data to predict tumour necrosis.

RESULTS:

Twenty-eight patients underwent 43 DEBDOX procedures for 45 HCC. Therapy had a significant effect as shown by a decrease in the mean size of the largest nodule (p = 0.02) and the sum of viable part of tumour sizes according to mRECIST criteria (p < 0.001). An objective response using mRECIST criteria was significantly correlated with mean tumour necrosis ≥90 % (p = 0.03). A complete response using mRECIST criteria enabled accurate prediction of complete tumour necrosis (p = 0.01). Correlations using RECIST criteria were not significant.

CONCLUSION:

Our data confirm the potential benefit of DEBDOX chemoembolisation as bridge therapy before LT, and they provide a rational basis for new studies focusing on recurrence-free survival after LT. Radiologic evaluation according to mRECIST criteria enables accurate prediction of tumour necrosis, whereas RECIST criteria do not.

• Authors: Xavier Pauwels, Mustapha Azahaf, Guillaume Lassailly, Géraldine Sergent, David Buob, Stéphanie Truant, Emmanuel Boleslawski, Alexandre Louvet, Vivianne Gnemmi, Valérie Canva, Philippe Mathurin, François-René Pruvot, Emmanuelle Leteurtre, Olivier Ernst, Sébastien Dharancy
• Journal: Cardiovascular and interventional radiology (Cardiovasc Intervent Radiol) Vol. 38 Issue 3 Pg. 685-92 (Jun 2015) ISSN: 1432-086X [Electronic] United States
• PMID: 25342136 (Publication Type: Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Doxorubicin

Topics

• Adult
• Aged
• Antibiotics, Antineoplastic (administration & dosage)
• Carcinoma, Hepatocellular (diagnostic imaging, therapy, ultrastructure)
• Chemoembolization, Therapeutic (methods)
• Doxorubicin (administration & dosage)
• Female
• Follow-Up Studies
• Humans
• Liver (diagnostic imaging, ultrastructure)
• Liver Neoplasms (diagnostic imaging, therapy, ultrastructure)
• Liver Transplantation
• Male
• Microspheres
• Middle Aged
• Preoperative Care (methods)
• Tomography, X-Ray Computed
• Treatment Outcome