Human leukocyte antigen-DRB1*1501 and DQB1*0602 alleles are cervical cancer protective factors among Uighur and Han people in Xinjiang, China.

Abstract

Human papillomavirus (HPV) infection is a major risk factor for cervical cancer. However, only some high risk human papillomavirus (HR-HPV)-infected women progress to cervical cancer, host immunogenetic factors human leukocyte antigen (HLA) may account for viral antigens presenting individually or together in the progression to cervical cancer. This study examined the association between the development of invasive cervical cancer (ICC) and the determinant factors including HLA-DRB1*1501 and DQB1*0602, HR-HPV infection among Chinese Uighur and Han populations. Blood samples, cervical swabs and biopsies were obtained from 287 patients with ICC (192 Uighurs and 95 Hans) and 312 healthy controls (218 Uighurs and 94 Hans). HPV DNA was detected by PCR and HLA-DRB1*1501 and DQB1*0602 alleles were performed using PCR-SSP method. HPV16 infection rates was significantly higher among Uighur and Han with ICC as compared to healthy controls (OR = 58.317; 95% CI: 39.663-85.744; OR = 33.778; 95% CI: 12.581-90.691; P < 0.05 for all). HLA-DRB1*1501 (OR = 0.305; 95% CI: 0.115-0.813; P < 0.05) and HLA-DRB1*1501-DQB1*0602 haplotype frequencies (OR = 0.274; 95% CI: 0.086-0.874; P < 0.05) were significantly reduced in Han ICC. The HLA-DQB1*0602 frequency significantly decreased among Uighur women with ICC (OR = 0.482; 95% CI: 0.325-0.716; P < 0.05). Similar tendencies were observed for DQB1*0602 with HPV16-positive ICC (OR = 0.550; 95% CI: 0.362-0.837; P < 0.05). This study suggests that HLA-DRB1*1501 and DQB1*0602 alleles may influence the immune response to HPV16 infection and decrease the risk of ICC among Uighurs and Hans in Xinjiang, China.

• Authors: Jian Ming Hu, Qi Sun, Ling Li, Chun Xia Liu, Yun Zhao Chen, Hong Zou, Li Juan Pang, Jin Zhao, Lan Yang, Yu Wen Cao, Xiao Bin Cui, Yan Qi, Wei Hua Liang, Wen Jie Zhang, Feng Li
• Journal: International journal of clinical and experimental pathology (Int J Clin Exp Pathol) Vol. 7 Issue 9 Pg. 6165-71 ( 2014) ISSN: 1936-2625 [Electronic] United States
• PMID: 25337265 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA, Viral
• HLA-DQ beta-Chains
• HLA-DQB1 antigen
• HLA-DRB1 Chains
• HLA-DRB1*15:01 antigen

Topics

• Adult
• Aged
• Asian People (genetics)
• Case-Control Studies
• Chi-Square Distribution
• China (epidemiology)
• DNA, Viral (genetics)
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• HLA-DQ beta-Chains (genetics)
• HLA-DRB1 Chains (genetics)
• Haplotypes
• Human Papillomavirus DNA Tests
• Human papillomavirus 16 (genetics)
• Humans
• Logistic Models
• Middle Aged
• Neoplasm Invasiveness
• Odds Ratio
• Papillomavirus Infections (ethnology, genetics, immunology, virology)
• Phenotype
• Polymerase Chain Reaction
• Predictive Value of Tests
• Protective Factors
• Risk Factors
• Uterine Cervical Neoplasms (ethnology, genetics, immunology, prevention & control, virology)