LDL-apheresis contributes to survival extension and renal function maintenance of severe diabetic nephropathy patients: a retrospective analysis.
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| Abstract | AIMS:
Low-density lipoprotein (LDL)-apheresis removes various molecules including LDL/oxidized LDL and inflammatory cytokines and recovers clinical laboratory parameters. It is not yet known whether these advantages of LDL-apheresis improve the prognosis of patients with diabetic nephropathy accompanied by nephrotic syndrome. METHODS: In this study, three groups of patients were retrospectively surveyed in a single center, and followed for approximately 3 years: an LDL-apheresis cohort (LDL-a; N = 20); a control cohort meeting the selection criterion of severe proteinuria ≥ 3g/24h (control-All; N = 55); and a subgroup of control-All with more severe proteinuria ≥ 5 g/24h (control-mSP; N = 10), and evaluated the outcomes as survival and renal dysfunction and death/renal dysfunction free rate. RESULTS: Death/renal dysfunction free rate was significantly higher in LDL-a than control-All (χ(2) = 4.50; P = 0.03) and control-mSP (χ(2) = 27.68; P < 0.001). CONCLUSION: These results suggest the possibilities which LDL-apheresis is considered to contribute to survival extension and renal function maintenance of severe diabetic nephropathy patients.
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| Authors | Eiichi Sato, Mayuko Amaha, Mayumi Nomura, Daisuke Matsumura, Yoshihiko Ueda, Tsukasa Nakamura |
| Journal | Diabetes research and clinical practice (Diabetes Res Clin Pract) Vol. 106 Issue 2 Pg. 241-6 (Nov 2014) ISSN: 1872-8227 [Electronic] Ireland |
| PMID | 25306260 (Publication Type: Journal Article) |
| Copyright | Copyright © 2014 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved. |
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