Weight loss reduces serum monocyte chemoattractant protein-1 concentrations in association with improvements in renal injury in obese men with metabolic syndrome.
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| Abstract | BACKGROUND:
Monocyte chemoattractant protein-1 (MCP-1) is involved in obesity-related renal injury. The aim of the present study was to examine the effects of weight loss on changes in MCP-1 and markers of renal injury, specifically serum cystatin C (S-CysC) and urinary N-acetyl glucosaminidase (UNAG), in obese people. METHODS: In this prospective study, 40 obese men with metabolic syndrome (MetS) participated in a 3-month dietary and exercise intervention. Twenty-eight subjects completed the study with a ≥5% weight loss. Circulating MCP-1, S-CysC and UNAG to creatinine ratio (UNCR) were determined before and after the weight loss program. RESULTS:
Obesity-associated components of MetS demonstrated significant improvements after the weight loss program. In addition, at baseline, circulating MCP-1 concentrations were positively correlated with UNCR and S-CysC levels. After weight loss, blood MCP-1 and UNCR levels were significantly decreased, but S-CysC was not affected. Using multiple linear regression analysis, there was a significant relationship between changes in UNCR and MCP-1 after adjusting for other potential confounding factors. CONCLUSIONS:
Weight loss may improve renal tubular injury by ameliorating obesity-related inflammation in obese men with MetS.
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| Authors | Chia-Po Fu, Wayne H-H Sheu, I-Te Lee, Wen-Jane Lee, Jun-Sing Wang, Kae-Woei Liang, Wen-Lieng Lee, Shih-Yi Lin |
| Journal | Clinical chemistry and laboratory medicine (Clin Chem Lab Med) Vol. 53 Issue 4 Pg. 623-9 (Mar 2015) ISSN: 1437-4331 [Electronic] Germany |
| PMID | 25301674 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't) |
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