RS11212617 is associated with metformin treatment response in type 2 diabetes in Shanghai local Chinese population.

Abstract

OBJECTIVE:

This study was designed to examine the relevance of single-nucleotide polymorphism (SNP) rs11212617 with treatment success in type 2 diabetes patients from Shanghai local Chinese Han population.

METHODS:

We genotyped rs11212617 in incident metformin users of type 2 diabetes patients from Shanghai local Chinese Han population. Association between rs11212617 and changes in HbA1c, fasting plasma glucose and postprandial glucose level were analysed.

RESULTS:

Two hundred and seventy-four incident metformin users were included in the study sample. The SNP rs11212617 was significantly associated with metformin response in Shanghai local Chinese Han population.

CONCLUSION:

The rs11212617 is associated with a reduction in HbA1c, fasting plasma glucose and postprandial glucose level. These results suggest that metformin treatment may be more efficacious in Shanghai and valuable for Chinese daily clinical practice.

• Authors: Y Zhou, Y Guo, W Ye, Y Wang, X Li, Y Tian, Z Liu, S Li, J Yan
• Journal: International journal of clinical practice (Int J Clin Pract) Vol. 68 Issue 12 Pg. 1462-6 (Dec 2014) ISSN: 1742-1241 [Electronic] India
• PMID: 25296556 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2014 John Wiley & Sons Ltd.

Chemical References

• Blood Glucose
• Glycated Hemoglobin A
• Hypoglycemic Agents
• Metformin

Topics

• Adult
• Aged
• Asian People (genetics)
• Blood Glucose (genetics)
• China
• Diabetes Mellitus, Type 2 (drug therapy)
• Dose-Response Relationship, Drug
• Female
• Glycated Hemoglobin (metabolism)
• Humans
• Hypoglycemic Agents (pharmacology, therapeutic use)
• Male
• Metformin (pharmacology, therapeutic use)
• Middle Aged
• Polymorphism, Single Nucleotide (drug effects)
• Treatment Outcome