Endothelial lipase-384A/C polymorphism is associated with acute coronary syndrome and lipid status in elderly Uygur patients in Xinjiang.

Abstract

OBJECTIVE:

To explore the relationship between the endothelial lipase (EL) gene promoter -384A/C polymorphism and acute coronary syndrome (ACS) and lipid status in elderly Uygur patients in Xinjiang.

METHODS:

The polymerase chain reaction-restriction fragment length polymorphism method was used to detect the EL gene promoter -384A/C genotype in 341 cases of elderly patients with ACS and 380 healthy subjects.

RESULTS:

In an elderly Chinese Han population, the EL-384A/C genotype and allele frequency distribution were significantly different between the ACS group and the control group (p<0.05); the frequency of the CC genotype in the ACS group was significantly higher than that in the control group (p<0.05). After adjusting for gender, age, diabetes, hypertension, smoking, hyperlipidemia, and other cardiovascular risk factors, the difference remains statistically significant (p<0.05). In the ACS group, C allele carriers had significantly higher serum triglycerides, total cholesterol, and low-density lipoprotein cholesterol concentrations compared to AA genotypes (all p<0.05).

CONCLUSION:

EL-384A/C polymorphism was significantly associated with the ACS and lipids profile in an elderly Uygur population in Xinjiang.

• Authors: Ding Huang, Xiang Xie, Yi-Tong Ma, Ying Huang, Xiang Ma
• Journal: Genetic testing and molecular biomarkers (Genet Test Mol Biomarkers) Vol. 18 Issue 11 Pg. 781-4 (Nov 2014) ISSN: 1945-0257 [Electronic] United States
• PMID: 25291260 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cholesterol, LDL
• Triglycerides
• LIPG protein, human
• Lipase

Topics

• Acute Coronary Syndrome (blood, ethnology, genetics)
• Aged
• Aged, 80 and over
• China (ethnology)
• Cholesterol, LDL (blood)
• Female
• Gene Frequency
• Genotype
• Humans
• Lipase (genetics, metabolism)
• Male
• Middle Aged
• Polymorphism, Restriction Fragment Length
• Triglycerides (blood)