Complex investigation of the effects of lambertianic acid amide in female mice under conditions of social discomfort.

Abstract

The effects of chronic administration of a new substance lambertianic acid amide and previously synthesized methyl ester of this acid were compared in female mice living under conditions of social discomfort. For modeling social discomfort, female mouse was housed for 30 days in a cage with aggressive male mouse kept behind a transparent perforated partition and observed its confrontations with another male mouse daily placed to the cage. The new agent more effectively than lambertianic acid methyl ester improved communicativeness and motor activity of animals, reduced hypertrophy of the adrenal glands, and enhanced catalase activity in the blood. These changes suggest that lambertianic acid amide produces a pronounced stress-protective effect under conditions of social discomfort.

• Authors: D F Avgustinovich, M K Fomina, I V Sorokina, T G Tolstikova
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 157 Issue 5 Pg. 583-7 (Sep 2014) ISSN: 1573-8221 [Electronic] United States
• PMID: 25257419 (Publication Type: Journal Article)

Chemical References

• Amides
• Blood Glucose
• Blood Proteins
• Carboxylic Acids
• Naphthalenes
• Triglycerides
• lambertianic acid
• Cholesterol

Topics

• Amides (chemistry)
• Animals
• Blood Glucose (analysis)
• Blood Proteins (analysis)
• Carboxylic Acids (chemistry, pharmacology)
• Cholesterol (blood)
• Enzyme-Linked Immunosorbent Assay
• Female
• Male
• Mice
• Naphthalenes (chemistry, pharmacology)
• Social Behavior Disorders (prevention & control)
• Triglycerides (blood)